Intravenous immunoglobulin therapy markedly ameliorates muscle weakness and severe pain in proximal diabetic neuropathy
Intravenous immunoglobulin therapy markedly ameliorates muscle weakness and severe pain in proximal diabetic neuropathy
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DOI：
10.1136/jnnp.2006.111302
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发表时间：
2007-08-01
影响因子：
11
通讯作者：
Sobue, G.
中科院分区：
文献类型：
--
作者：
Kawagashira, Y.;Watanabe, H.;Sobue, G.
一名57岁男性，患有2型糖尿病10年，表现为双腿肌力进行性丧失，股骨区疼痛和肌肉萎缩，体重明显减轻。入院时，他无法独自站立，只能坐轮椅。他还主诉下肢剧痛。他被诊断为近端糖尿病神经病变（PDN）的特征性临床和电生理特征。静脉注射免疫球蛋白治疗（IVIg 0.4 g/kgx 65天）显著减轻了腿部的严重疼痛和肌无力。最终，通过视觉疼痛量表评估的疼痛减轻了80%，肌肉力量也恢复良好，从而使患者能够用拐杖行走。目前的情况表明，静脉注射免疫球蛋白治疗可能是有效的缓解疼痛的PDN。
A 57-year-old man with type 2 diabetes mellitus for 10 years showed progressive loss of muscle strength in both legs, pain and muscle atrophy in the femoral region and significant weight loss. On admission, he could not stand alone and used a wheelchair. He also complained of severe pain in the lower extremities. He was diagnosed with proximal diabetic neuropathy (PDN) by characteristic clinical and electrophysiological features. Intravenous immunoglobulin therapy (IVIg 0.4 g/kgx65 days) markedly reduced the severe pain and muscle weakness in the legs. Eventually, pain assessed by the Visual Analogue Scale was relieved by 80% and muscle strength was also well recovered, thereby enabling the patient to walk with a cane. The present case suggests that IVIg therapy may be effective for the relief of pain in PDN.