In vivo endoscopic optical biopsy with optical coherence tomography
In vivo endoscopic optical biopsy with optical coherence tomography
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DOI：
10.1126/science.276.5321.2037
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发表时间：
1997-06-27
期刊：
影响因子：
56.9
通讯作者：
Fujimoto, JG
中科院分区：
文献类型：
--
作者：
Tearney, GJ;Brezinski, ME;Fujimoto, JG
当前的医学成像技术允许以范围从100微米到1毫米的分辨率可视化人体中的组织解剖结构。这些技术通常不够灵敏，无法检测与癌症和动脉粥样硬化等疾病相关的早期组织异常，这些疾病需要微米级分辨率。在这里，光学相干断层扫描被适配为允许用直径为1毫米的导管内窥镜对活体动物中的组织进行高速可视化。这种方法，被称为“光学活检”，用于获得10微米分辨率的兔胃肠道和呼吸道的横截面图像。
Current medical imaging technologies allow visualization of tissue anatomy in the human body at resolutions ranging from 100 micrometers to 1 millimeter. These technologies are generally not sensitive enough to detect early-stage tissue abnormalities associated with diseases such as cancer and atherosclerosis, which require micrometer-scale resolution. Here, optical coherence tomography was adapted to allow high-speed visualization of tissue in a living animal with a catheter-endoscope 1 millimeter in diameter. This method, referred to as ''optical biopsy,'' was used to obtain cross-sectional images of the rabbit gastrointestinal and respiratory tracts at 10-micrometer resolution.