Molecular characterization of neurally expressing genes in the para sodium channel gene cluster of drosophila.
Molecular characterization of neurally expressing genes in the para sodium channel gene cluster of drosophila.
复制标题
果蝇副钠通道基因簇中神经表达基因的分子特征。
DOI：
10.1093/genetics/142.3.879
复制
发表时间：
1996
期刊：
影响因子：
3.3
通讯作者：
Ganetzky,B
中科院分区：
文献类型：
--
作者：
Hong,CS;Ganetzky,B
为了阐明果蝇神经系统中编码主要钠通道的ParA的表达调控机制，我们试图通过绘制转录起始点和分析多线染色体Parain区域14D上游的区域来定位上游作用的调控元件。从这些研究中，我们发现该区域包含一组神经表达基因。在这里，我们报道了14D区域的基因组组织和该区域内的基因的分子特征，它们是：钙调素(CNX)、肌动蛋白相关蛋白14D(Arpl4D)、钙调神经磷酸酶A 14D(CnnAl4D)和染色体相关蛋白(Cap)。这些基因的紧密聚集，它们的神经元表达模式，以及它们与钠通道的表达、调节或调节相关的潜在功能，增加了这些基因代表一个功能相关的组的可能性，这些基因具有某种协调的调节机制。
To elucidate the mechanisms regulating expression ofpara, which encodes the major class of sodium channels in the Drosophila nervous system, we have tried to locate upstreamcis-acting regulatory elements by mapping the transcriptional start site and analyzing the region immediately upstream ofparain region 14D of the polytene chromosomes. From these studies, we have discovered that the region contains a cluster of neurally expressing genes. Here we report the molecular characterization of the genomic organization of the 14D region and the genes within this region, which are: calnexin (Cnx), actin related protein 14D (Arpl4D), calcineurin A 14D (CnnAl4D), and chromosome associated protein (Cap). The tight clustering of these genes, their neuronal expression patterns, and their potential functions related to expression, modulation, or regulation of sodium channels raise the possibility that these genes represent a functionally related group sharing some coordinate regulatory mechanism.