The effects of methyl β‐carboline‐3‐carboxylate on social interaction and locomotor activity when microinjected into the nucleus raphé dorsalis of the rat
The effects of methyl β‐carboline‐3‐carboxylate on social interaction and locomotor activity when microinjected into the nucleus raphé dorsalis of the rat
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β-咔啉-3-羧酸甲酯显微注射到大鼠中缝背核中对社交互动和运动活动的影响
DOI：
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发表时间：
1985
影响因子：
7.3
通讯作者：
M. Roberts
中科院分区：
文献类型：
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作者：
S. Hindley;A. Hobbs;I. Paterson;M. Roberts
1大鼠腹腔内和脑内注射β-咔啉-3-羧酸甲酯（βCCM）和脑内注射RO 15-1788。测量大鼠在社会互动测试中的表现，以确定βCCM诱导的社会互动变化是否部分由中缝背核（NRD）介导。2.腹膜内注射βCCM，2和4 mg kg−1，减少了社会互动。3脑内微量注射βCCM（10 - 0.1 ng，0.5 μl）至NRD减少了社会互动。NRD以外的注射没有这种效果。4脑内微量注射RO 15-1788（1 ng/0.5 μl）至NRD，单独给药时无影响，但可阻断脑内或腹腔注射βCCM引起的社会互动减少。5.当将R 15-1788微量注射到NRD外的部位时，没有观察到效果。6.社会交往的变化可能反映了焦虑的变化。NRD可能是βCCM表达抗焦虑作用的重要部位之一。
1 Intraperitoneal and intracerebral injections of methyl β‐carboline‐3‐carboxylate (βCCM) and intracerebral injections of RO 15–1788 were given to rats. The performance of the rats in the social interaction test was measured to determine if changes in social interaction induced by βCCM were mediated in part by the nucleus raphé dorsalis (NRD). 2 Intraperitoneal injections of βCCM, 2 and 4 mg kg−1, reduced social interaction. 3 Intracerebral microinjections of βCCM (10‐0.1 ng in 0.5 μl) into the NRD reduced social interaction. Injections outside the NRD did not have this effect. 4 Intracerebral microinjections of RO 15–1788 (1 ng in 0.5 μl) into the NRD had no effect when given alone, but blocked the reduction in social interaction caused by intracerebral or intraperitoneal injections of βCCM. 5 No effect was observed when R 15–1788 was microinjected into sites outside the NRD. 6 Changes in social interaction may reflect changes in anxiety. The NRD may be one of the important sites for the expression of the anxiogenic actions of βCCM.