Age-related changes in primary somatosensory cortex of rats:: evidence for parallel degenerative and plastic-adaptive processes
Age-related changes in primary somatosensory cortex of rats:: evidence for parallel degenerative and plastic-adaptive processes
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DOI：
10.1016/s0149-7634(02)00061-1
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发表时间：
2002-11-01
影响因子：
8.2
通讯作者：
Dinse, HR
中科院分区：
文献类型：
--
作者：
Godde, B;Berkefeld, T;Dinse, HR
老年大鼠表现出特征性的感觉运动状态下降，最显著的表现是后肢损伤，导致后爪感觉刺激显著减少。我们回顾了最近的研究，利用光学成像和电生理记录，调查老化对躯体感觉皮层的影响，并确定与年龄相关的变化方面的退化或塑性适应。对于皮质后爪代表，地图的大小减少，感受野扩大和反应强度降低。在同一个体的前爪表征中未报告这些变化，然而，在前爪和后爪表征中，反应潜伏期和脑血流均受到影响。退化最好地解释了乳酸和血流量的变化，但区域和特定的地图，感受野和反应强度的变化是由感觉输入减少引起的可塑性现象引起的。虽然退行性变化不能通过丰富的环境条件或应用Ca2+阻滞剂来改变，但在这些条件下，塑性变化是完全可逆的。我们讨论了这些发现的影响，在老年认知功能和可能的治疗与年龄有关的变化，在人类受试者。(C)2002爱思唯尔科技有限公司版权所有。
Aged rats show a characteristic decline of the sensorimotor state, most strikingly expressed in an impairment of the hindlimbs leading to significantly reduced sensory stimulation on the hindpaw. We review recent studies using optical imaging and electrophysiological recordings to investigate the effects of aging on somatosensory cortex and to identify age-related changes in terms of degeneration or plastic adaptation. For the cortical hindpaw representation, reduction of map size, receptive field enlargement and reduced response strength were described. None of these changes were reported in the forepaw representation in the same individual, however, in both the fore-and hindpaw representations response latencies and cerebral blood flow were affected. Changes of latencies and blood flow are best explained by degeneration, but the regional and specific changes of maps, receptive fields and response strength by plastic phenomena arising from the reduced sensory inputs. While the degenerative changes are not modifiable by enriched environmental conditions or application of Ca2+ blocker, the plastic changes were fully reversible under these conditions. We discuss the implications of these findings for cognitive functions at old age and possible treatments of age-related changes in human subjects. (C) 2002 Elsevier Science Ltd. All rights reserved.