Synthetic applications of a three-component Mannich reaction. Total synthesis of IL-6 inhibitor (+)-madindoline A and B
Synthetic applications of a three-component Mannich reaction. Total synthesis of IL-6 inhibitor (+)-madindoline A and B
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DOI：
10.1016/j.tetlet.2006.07.083
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发表时间：
2006-09-18
影响因子：
1.8
通讯作者：
Omura, Satoshi
中科院分区：
文献类型：
--
作者：
Hirose, Tomoyasu;Sunazuka, Toshiaki;Omura, Satoshi
采用3 α-羟基呋喃并吲哚啉（3）、β-酮酯和甲醛的三组分Mannich反应作为一种有效而简洁的方法来合成天然存在的（+）-Madindolines A（1）和B（2）。本文介绍了3的曼尼希反应的范围和局限性。(c)2006爱思唯尔有限公司保留所有权利。
A three-component Mannich reaction of 3a-hydroxyfuroindoline (3), beta-ketoester and formaldehyde was employed as an efficient and concise method to synthesize naturally-occurring (+)-Madindolines A (1) and B (2). The scope and limitations of the Mannich reaction with 3 are described. (c) 2006 Elsevier Ltd. All rights reserved.