Worms can worsen malaria: towards a new means to roll back malaria?
Worms can worsen malaria: towards a new means to roll back malaria?
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DOI：
10.1016/j.pt.2005.06.011
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发表时间：
2005-08-01
影响因子：
9.6
通讯作者：
Sokhna, C
中科院分区：
文献类型：
--
作者：
Druilhe, P;Tall, A;Sokhna, C
非洲和亚洲的最新研究表明，不同的蠕虫感染会对疟疾感染的临床结果产生不利影响。这表明蠕虫可以影响疟原虫免疫力的获得。蠕虫可能会成为评估疟疾控制干预措施（包括临床试验中的疫苗原型）效果的混杂因素。这些观察结果具有根本性和实际的意义；如果蠕虫对疟疾的有害作用得到证实，蠕虫治疗将为减少疟疾提供一种负担得起、高效且新颖的方法。通过这篇文章，我们希望引导其他人在不同地区进行类似的研究。
Recent studies in Africa and Asia indicate that different helminthic infections adversely affect the clinical outcome of malaria infections. This suggests that helminths can influence the acquisition of immunity against Plasmodium. Worms could constitute a confounding factor in the assessment of efficacy of malaria-control intervention, including vaccine prototypes in clinical trials. These observations have fundamental and practical consequences; if the deleterious effect of worms on malaria is confirmed, treatment of helminths would offer an affordable, strongly effective and novel means to roll back malaria. With this article, we hope to induce others to conduct similar studies in different regions.