Relationship between bleeding time, aspirin and the PlA1/A2 polymorphism of platelet glycoprotein IIIa
Relationship between bleeding time, aspirin and the PlA1/A2 polymorphism of platelet glycoprotein IIIa
复制标题
出血时间、阿司匹林与血小板糖蛋白IIIa PlA1/A2多态性的关系
DOI：
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发表时间：
2000
影响因子：
6.5
通讯作者：
W. Węgrzyn
中科院分区：
文献类型：
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作者：
A. Szczeklik;A. Undas;M. Sanak;M. Frolow;W. Węgrzyn
编码糖蛋白IIIa的基因从T到C的单核苷酸转换导致了常见的双等位基因多态性Leu-33PLA1/A2(→/A2)。本文对80例20~25 的健康男性进行了PLA1/A2基因多态性与血小板功能的关系研究。服用阿司匹林前，PLA2携带者的出血时间(BT)比PlA1/A1等位基因携带者短。在摄入30 0 mg阿司匹林后4 h，BT延长，组间差异增大。在26名PLA2等位基因携带者中，有7名携带阿司匹林的人平均缩短了30 S的BT，而在54名PlA1/A1基因型的受试者中，只有1人这样做。因此，基础状态和服用阿司匹林后的BT均取决于糖蛋白IIIa的PlA1/A2多态。携带PLA2等位基因的人似乎对阿司匹林的抗血栓作用更具抵抗力。
A single nucleotide T to C transition of the gene encoding glycoprotein IIIa leads to a common diallelic polymorphism Leu‐33→Pro (PLA1/A2). We studied the relationship between the PlA1/A2 polymorphism and platelet function in 80 healthy men, aged 20–25 years. Before aspirin ingestion, bleeding time (BT) was shorter in carriers of the PlA2 than in carriers of the PlA1/A1 allele. At 4 h after ingestion of 300 mg of aspirin, BT became prolonged, and the intergroup difference was enhanced. In seven out of 26 PLA2 allele carriers, aspirin shortened BT on average by 30 s, compared with only one among 54 subjects with the PlA1/A1 genotype. Thus, BT both at baseline and after aspirin depends on the PlA1/A2 polymorphism of glycoprotein IIIa. Carriers of the PlA2 allele appear to be more resistant to the antithrombotic action of aspirin.