Effects of microiontophoretic application of cocaine, alone and with receptor antagonists, upon the neurons of the medial prefrontal cortex, nucleus accumbens and caudate nucleus of rats.
Effects of microiontophoretic application of cocaine, alone and with receptor antagonists, upon the neurons of the medial prefrontal cortex, nucleus accumbens and caudate nucleus of rats.
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单独使用可卡因和与受体拮抗剂一起使用微离子电渗疗法对大鼠内侧前额皮质、伏核和尾状核神经元的影响。
DOI：
10.1016/0028-3908(90)90098-c
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发表时间：
1990
影响因子：
4.7
通讯作者：
Dafny,N
中科院分区：
文献类型：
--
作者：
Qiao,JT;Dougherty,PM;Wiggins,RC;Dafny,N
本文研究了102个神经元在尾状核(CN)、内侧前额叶皮质(MPC)、伏隔核(NAC)和对照部位丘脑外侧核(LT)的自发细胞外电活动。可卡因抑制了大多数细胞的自发活动，这些细胞来自除外侧丘脑以外的所有区域。临床上用于治疗可卡因戒断的地塞帕明也抑制了尾状核的神经元活动。此外，在被测试的三种受体拮抗剂舒必利、甲基丝氨酸甲酯和纳洛酮中，只有多巴胺拮抗剂(舒必利)影响可卡因诱导的神经元反应。这项研究进一步强调了中脑多巴胺能系统在这种重要的滥用药物的药理作用中的重要性。
The spontaneous extracellular electrical activity of 102 neurons, within the caudate nucleus (CN), medial prefrontal cortex (MPC), nucleus accumbens (NAc) and a control site, the lateral thalamic nucleus (LT), was studied. Cocaine depressed spontaneous activity in the majority of the cells studied from all regions except the lateral thalamus. Desipramine, which has been used clinically for the treatment of withdrawal of cocaine, also depressed neuronal activity in the caudate nucleus. In addition, of the three receptor antagonists tested, sulpiride, methysergide and naloxone, only the dopamine antagonist (sulpiride) affected cocaine-induced neuronal responses. This study further emphasizes the emerging importance of midbrain dopaminergic systems in the pharmacological effects of this important drug of abuse.