What Are the Top 10 Research Questions in the Treatment of Inflammatory Bowel Disease? A Priority Setting Partnership with the James Lind Alliance
What Are the Top 10 Research Questions in the Treatment of Inflammatory Bowel Disease? A Priority Setting Partnership with the James Lind Alliance
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DOI：
10.1093/ecco-jcc/jjw144
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发表时间：
2017-02-01
影响因子：
8
通讯作者：
McLaughlin, John
中科院分区：
文献类型：
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作者：
Hart, Ailsa L.;Lomer, Miranda;McLaughlin, John
背景和目的：关于炎症性肠病的最佳治疗方法和策略仍存在许多不确定性。确定治疗的研究优先事项需要医疗保健专业人员，患者和支持患者的组织之间的伙伴关系。我们的目的是使用的詹姆斯林德联盟优先设置伙伴关系，这已被用于其他疾病领域的结构，以确定和优先解决未回答的问题有关治疗炎症性肠病。方法：詹姆斯林德优先设置伙伴关系使用的方法商定，并通过在其他疾病领域的工作与患者和临床医生：以确定有关治疗的不确定性;以协商一致的方式商定一个研究不确定性的优先顺序清单;然后将这些不确定性转化为适合假设检验的研究问题;最后将结果提交给研究委托机构考虑资助。结果：在初步调查中，共收集了531名受访者的1636个不确定因素，其中包括22%的医疗保健专业人员和78%的患者和护理人员。使用优先级设置伙伴关系的严格应用程序，该列表被提炼为炎症性肠病的十大研究优先事项。最高优先事项是：确定治疗策略，以优化疗效、安全性和成本效益;并根据患者的病程和治疗反应对患者进行分层。饮食和症状控制[疼痛，尿失禁和疲劳]的主题也被优先考虑。结论：涉及多学科临床医生，患者和组织支持患者的伙伴关系已经确定了炎症性肠病患者治疗的十大研究重点。
Background and Aims: Many uncertainties remain regarding optimal therapies and strategies for the treatment of inflammatory bowel disease. Setting research priorities addressing therapies requires a partnership between health care professionals, patients and organisations supporting patients. We aimed to use the structure of the James Lind Alliance Priority Setting Partnership, which has been used in other disease areas, to identify and prioritise unanswered questions about treatments for inflammatory bowel disease.Methods: The James Lind Priority Setting Partnership uses methods agreed and adopted in other disease areas to work with patients and clinicians: to identify uncertainties about treatments; to agree by consensus a prioritised list of uncertainties for research; then to translate these uncertainties into research questions which are amenable to hypothesis testing; and finally to take results to research commissioning bodies to be considered for funding.Results: A total of 1636 uncertainties were collected in the initial survey from 531 respondents, which included 22% health care professionals and 78% patients and carers. Using the rigorously applied processes of the priority setting partnership, this list was distilled down to the top 10 research priorities for inflammatory bowel disease. The top priorities were: identifying treatment strategies to optimise efficacy, safety and cost-effectiveness; and stratifying patients with regard to their disease course and treatment response. Diet and symptom control [pain, incontinence and fatigue] were also topics which were prioritised.Conclusions: A partnership involving multidisciplinary clinicians, patients and organisations supporting patients has identified the top 10 research priorities in the treatment of patients with inflammatory bowel disease.