Locomotion-dependent remapping of distributed cortical networks
Locomotion-dependent remapping of distributed cortical networks
复制标题
DOI：
10.1038/s41593-019-0357-8
复制
发表时间：
2019-05-01
影响因子：
25
通讯作者：
Mrsic-Flogel, Thomas D.
中科院分区：
文献类型：
--
作者：
Clancy, Kelly B.;Orsolic, Ivana;Mrsic-Flogel, Thomas D.
新皮层区域之间的相互作用是流体和状态依赖的，但单个神经元如何耦合到皮层范围的网络动力学仍然知之甚少。我们将初级视觉（V1）和压后（RSP）皮层神经元的尖峰与背侧皮层的活动相关联，同时记录宽场钙成像。神经元与整个皮层表面的活动的独特和可重复的模式相关;而一些发射主要与他们的本地区域，其他耦合到远端区域的活动。远端耦合的程度是通过神经元与局部网络的相关程度来预测的。运动引起的大脑状态变化加强了V1神经元与高级视觉和运动区的联系，同时加强了RSP神经元与感觉皮层的远端联系。因此，不同的耦合个别神经元的皮层范围内的活动模式是通过在特定区域的方式运行，导致在运动过程中的皮层处理模式的转变进行重构。
The interactions between neocortical areas are fluid and state-dependent, but how individual neurons couple to cortex-wide network dynamics remains poorly understood. We correlated the spiking of neurons in primary visual (V1) and retrosplenial (RSP) cortex to activity across dorsal cortex, recorded simultaneously by widefield calcium imaging. Neurons were correlated with distinct and reproducible patterns of activity across the cortical surface; while some fired predominantly with their local area, others coupled to activity in distal areas. The extent of distal coupling was predicted by how strongly neurons correlated with the local network. Changes in brain state triggered by locomotion strengthened affiliations of V1 neurons with higher visual and motor areas, while strengthening distal affiliations of RSP neurons with sensory cortices. Thus, the diverse coupling of individual neurons to cortex-wide activity patterns is restructured by running in an area-specific manner, resulting in a shift in the mode of cortical processing during locomotion.