Stem cell therapy - Hype or hope? A review.
Stem cell therapy - Hype or hope? A review.
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干细胞疗法 - 炒作还是希望？评论。
DOI：
10.4103/0972-0707.58329
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发表时间：
2009-10
期刊：
影响因子：
--
通讯作者：
Nadig, Roopa R
中科院分区：
文献类型：
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作者：
Nadig, Roopa R
虽然人类已经知道失去组织的再生已经有好几年了，但直到最近，再生医学/牙科的研究才获得了动力，并避开了分子生物学领域的戏剧性而又科学的进步。随着对口腔/牙齿组织再生中生物学概念的理解不断加深，再加上对干细胞的实验，可能会导致牙科和口腔疾病治疗设备的范式转变，最终导致对“生物学问题的生物学解决方案”的强烈搜索。干细胞已成功地从包括口面部组织在内的多种人体组织中分离出来。来自开创性研究的初步证据已经证明了干细胞为迄今为止击败现代医疗的各种危及生命的疾病提供的可能突破。到目前为止，收集到的证据推动了许多探索干细胞作用及其多种牙科应用的研究。这篇综述将带您了解干细胞的起源，它们的性质，特征，当前的研究及其潜在的应用。它还重点介绍了在将实验室结果转化为成功的临床应用之前，我们必须克服的各种挑战和障碍，这些挑战和障碍预示着再生牙科的曙光。
While the regeneration of a lost tissue is known to mankind for several years, it is only in the recent past that research on regenerative medicine/dentistry has gained momentum and eluded the dramatic yet scientific advancements in the field of molecular biology. The growing understanding of biological concepts in the regeneration of oral/dental tissues coupled with experiments on stem cells is likely to result in a paradigm shift in the therapeutic armamentarium of dental and oral diseases culminating in an intense search for “biological solutions to biological problems.” Stem cells have been successfully isolated from variety of human tissues including orofacial tissues. Initial evidence from pioneering studies has documented the likely breakthrough that stem cells offer for various life-threatening diseases that have so far defeated modern medical care. The evidence gathered so far has propelled many elegant studies exploring the role of stem cells and their manifold dental applications. This review takes you on a sojourn of the origin of stem cells, their properties, characteristics, current research, and their potential applications. It also focuses on the various challenges and barriers that we have to surmount before translating laboratory results to successful clinical applications heralding the dawn of regenerative dentistry.