Synthetic Ecology of Microbes: Mathematical Models and Applications.
Synthetic Ecology of Microbes: Mathematical Models and Applications.
复制标题
DOI：
10.1016/j.jmb.2015.10.019
复制
发表时间：
2016-02-27
影响因子：
5.6
通讯作者：
Segrè D
中科院分区：
文献类型：
--
作者：
Zomorrodi AR;Segrè D
随着天然微生物群落在地球生命许多方面不可或缺的作用被揭示，具有新颖功能的合成微生物群落的自下而上的工程正在成为工程单物种系统的一个有吸引力的替代方案。在这里，我们总结了最近关于合成微生物群落的工作，特别强调环境可持续性和人类健康方面的开放挑战和机遇。接下来，我们对数学方法进行批判性概述，从现象学到机械论，这些方法可用于破译控制微生物生态系统的功能、动力学和进化的原理。最后，我们提出了对微生物生态系统和合成生态学需要进一步发展的关键方面的展望，包括需要更有效的算法以及更好地整合经验方法和模型驱动分析，改进基因功能注释的重要性，以及用作合成群落构建块的特征明确的生物体标准化库的价值。
As the indispensable role of natural microbial communities in many aspects of life on Earth is uncovered, the bottom-up engineering of synthetic microbial consortia with novel functions is becoming an attractive alternative to engineering single-species systems. Here, we summarize recent work on synthetic microbial communities with a particular emphasis on open challenges and opportunities in environmental sustainability and human health. We next provide a critical overview of mathematical approaches, ranging from phenomenological to mechanistic, which can be used to decipher the principles that govern the function, dynamics and evolution of microbial ecosystems. Finally, we present our outlook on key aspects of microbial ecosystems and synthetic ecology that require further developments, including the need for more efficient algorithms and a better integration of empirical methods and model-driven analysis, the importance of improving gene function annotation, and the value of a standardized library of well-characterized organisms to be used as building blocks of synthetic communities.