Looking back: corticothalamic feedback and early visual processing
Looking back: corticothalamic feedback and early visual processing
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DOI：
10.1016/j.tins.2006.05.002
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发表时间：
2006-06-01
影响因子：
15.9
通讯作者：
Sillito, Adam M.
中科院分区：
文献类型：
--
作者：
Cudeiro, Javier;Sillito, Adam M.
虽然曾经被认为是通向大脑皮层的一个简单的感觉中继，但越来越明显的是，丘脑在持续不断的感觉输入和认知的处理过程中发挥着作用。这涉及到广泛的皮质反馈连接，以及这些连接与局部丘脑回路和其他汇聚输入的相互作用。本文以猫科动物视觉系统为主要模型，从系统功能的综合角度对该领域的一些最新进展进行了综述。由嗜离子性和代谢性谷氨酸受体介导的皮质反馈，以及由神经调节剂一氧化氮介导的效应，都在将丘脑机制整合到皮质回路中发挥作用。关键的一点是，更高层次的感觉机制的视角改变和调节了丘脑回路，以优化对外部世界有意义的表征的抽象。这篇综述是《认知的神经基础》特刊的一部分。
Although once regarded as a simple sensory relay on the way to the cortex, it is increasingly apparent that the thalamus has a role in the ongoing moment-by-moment processing of sensory input and in cognition. This involves extensive corticofugal feedback connections and the interplay of these with the local thalamic circuitry and the other converging inputs. Here, using the feline visual system as the primary model, some of the latest developments in this field are reviewed and placed in the perspective of an integrated view of system function. Cortical feedback mediated by ionotropic and metabotropic glutamate receptors, and effects mediated by the neuromodulator nitric oxide, all have a role in integrating the thalamic mechanism into the cortical circuit. The essential point is that the perspective of higher-level sensory mechanisms shifts and modulates the thalamic circuitry in ways that optimize abstraction of a meaningful representation of the external world. This review is part of the TINS special issue on The Neural Substrates of Cognition.