Effects of Capsaicin on Lipid Catabolism in 3T3-L1 Adipocytes
Effects of Capsaicin on Lipid Catabolism in 3T3-L1 Adipocytes
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DOI：
10.1002/ptr.3339
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发表时间：
2011-06-01
影响因子：
7.2
通讯作者：
Kim, Yangha
中科院分区：
文献类型：
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作者：
Lee, Mak-Soon;Kim, Chong-Tai;Kim, Yangha
辣椒素（8-甲基-n -香兰素-6-壬胺）是红辣椒的一种辛辣成分，据报道可以减少啮齿动物的体重增加和肥胖。本研究探讨了辣椒素对分化3T3-L1脂肪细胞脂质分解代谢的影响。辣椒素以浓度依赖的方式降低细胞内脂质含量。在培养基中加入辣椒素增加了甘油的释放量。激素敏感脂肪酶（HSL）、肉毒碱棕榈酰转移酶- α (cpti - α)和解偶联蛋白2 （UCP2）等参与脂质分解代谢的基因mRNA水平显著上调。这些结果表明，辣椒素通过增加脂肪细胞中三酰甘油的水解来发挥其溶脂作用，并且这些作用至少部分是通过调节参与脂质分解代谢途径的多个基因的表达来介导的，如HSL和CPT-I α，以及参与产热的基因，如UCP2。版权所有John Wiley & Sons， Ltd。
Capsaicin (8-methyl-N-vanillyl-6-nonenamide) is a pungent ingredient of red peppers, and has been reported to reduce body weight gain and adiposity in rodents. The present study investigated the effects of capsaicin on lipid catabolism in differentiated 3T3-L1 adipocytes. Capsaicin decreased the intracellular lipid content in a concentration-dependent manner. The release of glycerol into the medium was increased by the addition of capsaicin. The mRNA levels of genes involved in lipid catabolism such as hormone sensitive lipase (HSL), carnitine palmitoyl transferase-I alpha (CPTI-alpha) and uncoupling protein 2 (UCP2) were up-regulated significantly. These results suggest that capsaicin exerts its lipolytic action by increasing the hydrolysis of triacylglycerol in adipocytes, and that these effects are mediated at least partially by regulation of the expression of multiple genes that are involved in the lipid catabolic pathway, such as HSL and CPT-I alpha, and those involved in thermogenesis such as UCP2. Copyright (C) 2010 John Wiley & Sons, Ltd.