Obstructive Sleep Apnea, Masked Hypertension, and Arterial Stiffness in Men
Obstructive Sleep Apnea, Masked Hypertension, and Arterial Stiffness in Men
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DOI：
10.1038/ajh.2009.246
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发表时间：
2010-03-01
影响因子：
3.2
通讯作者：
Krieger, Eduardo M.
中科院分区：
文献类型：
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作者：
Drager, Luciano F.;Diegues-Silva, Luzia;Krieger, Eduardo M.
背景阻塞性睡眠呼吸暂停(OSA)是高血压的一个既定原因，然而，考虑到动态血压监测(ABPM)方法，目前尚不清楚OSA患者中是否存在隐性高血压的频率以及OSA是否对动脉僵硬有独立的作用。我们评估了61名男性正常血压参与者，其中61名男性血压水平通过多导睡眠图确定为15次/小时)，18名年龄和体重指数匹配的对照组(AHL=135或>；对照组和OSA患者的AHI和最低血氧饱和度分别为26+/-16和90+/-2vs528+/-210次/小时和75+/-10%，P<；0001。与对照组相比，阻塞性睡眠呼吸暂停综合征患者的办公室收缩压(113+/-9vs118+/-10 mm Hg，P=005)和未调整的隐性高血压比例(2例对照组(11.1%)对13例患者(302%)，P<；005)PWV分别为87+/-0.7，9.4+/-1.0，10.6+/-1.1m/S(P<；多因素回归分析显示，白天ABPM和最低血氧饱和度与PWV独立相关(校正R2=0 34，P<0 0 1)。结论阻塞性睡眠呼吸暂停综合征患者的隐性高血压未调整率高于对照组。低氧饱和度与动脉僵硬独立相关
BACKGROUNDObstructive sleep apnea (OSA) is an established cause of hypertension However, it is not clear whether the frequency of masked hypertension in patients with OSA and whether OSA have an independent role on arterial stiffness taking into account ambulatory blood pressure (BP) monitoring (ABPM)METHODSWe evaluated 61 male normotensive participants as determined by casual clinic BP level = 15 events/hour by polysomnography) and 18 age- and body mass index-matched controls without OSA (AHl = 135 or >= 85 mm HgRESULTSThe AHI and lowest oxygen saturation were 26 +/- 16 and 90 +/- 2 vs 528 +/- 210 events/hour and 75 +/- 10% for controls and OSA patients, respectively, P < 0 001. Compared with controls, patients with OSA had higher office systolic BP (113 +/- 9 vs 118 +/- 10 mm Hg, P=0 05) and a higher unadjusted proportion of masked hypertension (2 controls (11.1%)vs 13 patients (30 2%), P < 005) PWV was 87 +/- 0.7, 9.4 +/- 1.0, and 10.6 +/- 1.1 m/s in the control, OSA without and with masked hypertension groups, respectively (P < 0 01 for each comparison) Multiple regression showed that systolic daytime ABPM and the lowest oxygen saturation were independently related to PWV (adjusted R-2 = 0 34, P < 0 01)CONCLUSIONSPatients with OSA presented a higher unadjusted rate of masked hypertension than matched controls. Lowest oxygen saturation has an independent association with arterial stiffness