On residues in the disallowed region of the Ramachandran map
On residues in the disallowed region of the Ramachandran map
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DOI：
10.1002/bip.10051
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发表时间：
2002-03-01
期刊：
影响因子：
2.9
通讯作者：
Chakrabarti, P
中科院分区：
文献类型：
--
作者：
Pal, D;Chakrabarti, P
的非glycyl残基的构象中不允许的Ramachandran情节的发生分析。Ser、Asn、Thr和Cys具有最高的表现出这种构象的倾向，而支链脂肪族残基最低。残基群集在五个区域，并有一些趋势的类型的残基和它们的侧链构象（X，）占据这些。大多数残基位于螺旋和链的边缘以及短环中，并参与不同类型的弱稳定相互作用。已鉴定出一种结构基序，其中不允许构象的残基作为短3（10）-螺旋的第一个残基出现。基于相邻残基的类型、在三维结构中的位置和可及性，存在与蛋白质结构中顺式肽键的出现的相似性。(C)2002年John Wiley Sons，Inc.
An analysis of the occurrence of nonglycyl residues in conformations disallowed in the Ramachandran plot is presented. Ser, Asn, Thr, and Cys have the highest propensities to exhibit such conformations, and the branched aliphatic residues the lowest. Residues cluster in five regions and there are some trends in the types of residues and their side-chain conformations (X,) occupying these. Majority of the residues are found at the edge of helices and strands and in short loops, and are involved in different types of weak, stabilizing interactions. A structural motif has been identified where a residue in disallowed conformation occurs as the first residue of a short 3(10)-helix. On the basis of the types of neighboring residues, the location in the three-dimensional structure and accessibility, there are similarities with the occurrence of cis peptide bonds in protein structures. (C) 2002 John Wiley Sons, Inc.