Head and Neck Tumors: Assessment of Perfusion-Related Parameters and Diffusion Coefficients Based on the Intravoxel Incoherent Motion Model
Head and Neck Tumors: Assessment of Perfusion-Related Parameters and Diffusion Coefficients Based on the Intravoxel Incoherent Motion Model
复制标题
DOI：
10.3174/ajnr.a3227
复制
发表时间：
2013-02-01
影响因子：
3.5
通讯作者：
Nakamura, T.
中科院分区：
文献类型：
--
作者：
Sumi, M.;Nakamura, T.
背景和目的：IVIM MR成像通过单个弥散加权MR图像提供灌注和弥散信息。我们确定是否PP和D不同的各种类型的头部和颈部tumors.MATERIALS和METHODS：研究队列包括123头和颈部肿瘤：30 SCC，28良性和20恶性SG肿瘤，36淋巴瘤，9神经鞘瘤。基于IVIM模型，使用0、500和1000 s/mm（2）的b值确定D和PP值。结果：PP值（淋巴瘤，0.09 ± 0.04; SCC，0.15 ± 0.04;和恶性SG肿瘤，0.22 ± 0.07）和D值（分别为0.47 +/- 0.07 x 10（-3）mm（2）/s、0.82 +/- 0.17 x 10（-3）mm（2）/s和1.03 +/- 0.16 x 10（-3）mm（2）/s）在恶性肿瘤之间存在显著差异（P <0.01）。多形性腺瘤（0.13 +/- 0.02和1.44 +/- 0.39 x 10（-3）mm（2）/s）和Warthin瘤（0.19 +/- 0.04和0.73 +/- 0.22 x 10（-3）mm（2）/s）之间的这些值也有显著差异（P <0.001）。恶性SG肿瘤的PP值与多形性腺瘤的PP值有显著差异（P = .001），恶性SG肿瘤的D值与多形性腺瘤（P = .002）和Warthin瘤（P = .007）有显著差异。神经鞘瘤具有较大的PP值（0.23 ± 0.08）和D值（1.26 ± 0.20 × 10（-3）mm（2）/s），与某些SG肿瘤类型的PP值和D值有很大重叠。
BACKGROUND AND PURPOSE: IVIM MR imaging provides perfusion and diffusion information with a single diffusion-weighted MR image. We determined whether PP and D differ among various types of head and neck tumors.MATERIALS AND METHODS: The study cohort included 123 head and neck tumors: 30 SCCs, 28 benign and 20 malignant SG tumors, 36 lymphomas, and 9 schwannomas. The D and PP values were determined by using b-values of 0, 500, and 1000 s/mm(2) based on the IVIM model.RESULTS: The PP values (lymphomas, 0.09 0.04; SCCs, 0.15 +/- 0.04; and malignant SG tumors, 0.22 +/- 0.07) and D values (0.47 +/- 0.07 x 10(-3) mm(2)/s, 0.82 +/- 0.17 x 10(-3) mm(2)/s, and 1.03 +/- 0.16 x 10(-3) mm(2)/s, respectively) were significantly different among the malignant tumors (P < .01). These values were also significantly different between pleomorphic adenomas (0.13 +/- 0.02 and 1.44 +/- 0.39 x 10(-3) mm(2)/s) and Warthin tumors (0.19 +/- 0.04 and 0.73 +/- 0.22 x 10(-3) mm(2)/s) (P < .001). The PP values of malignant SG tumors were significantly different from those of pleomorphic adenomas (P = .001) and the D values of the malignant SG tumors were significantly different from those of pleomorphic adenomas (P = .002) and Warthin tumors (P = .007). Schwannomas had large PP (0.23 +/- 0.08) and D values (1.26 +/- 0.20 x 10(-3) mm(2)/s), greatly overlapping those of some SG tumor types.CONCLUSIONS: Head and neck tumors had distinctive PP and D values by using IVIM MR imaging.