Generation of an induced pluripotent stem cell line, FJMUUHi001-A, from a hereditary Parkinson's disease patient with homozygous mutation of c.189dupA in PARK7
Generation of an induced pluripotent stem cell line, FJMUUHi001-A, from a hereditary Parkinson's disease patient with homozygous mutation of c.189dupA in PARK7
复制标题
从患有 PARK7 中 c.189dupA 纯合突变的遗传性帕金森病患者中产生诱导多能干细胞系 FJMUUHi001-A
DOI：
10.1016/j.scr.2021.102175
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发表时间：
2021-01-20
影响因子：
1.2
通讯作者：
Ye, Qin-Yong
中科院分区：
文献类型：
--
作者：
Chen, Zhi-Ting;Zhao, Zhen-Hua;Ye, Qin-Yong
PARK7 mutations are accountable for the inherited Parkinson's disease. An induced pluripotent stem cell (iPSC) line FJMUUHi001-A was generated by expressing five reprogramming factors, OCT3/4, SOX2, c-MYC, KLF4 and BCL-XL, in peripheral blood mononuclear cells from a 32-year old patient carrying a homozygous mutation of c.189dupA in PARK7. The iPSCs with a normal karyotype had the abilities to differentiate into three germ layers and expressed pluripotency markers without detectable residual plasmids. The cell line FJMUUHi001-A carrying the truncating protein PARK7 could be a useful tool to help comprehend the function of PARK7 in the iPSCs and differentiated cells from them.
