Yes-associated protein expression in paired primary and local recurrent breast cancer and its clinical significance
Yes-associated protein expression in paired primary and local recurrent breast cancer and its clinical significance
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DOI：
10.1016/j.currproblcancer.2018.12.005
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发表时间：
2019-10-01
影响因子：
2.6
通讯作者：
Xiao, Zhi
中科院分区：
文献类型：
--
作者：
Ding, Nianhua;Huang, Ting;Xiao, Zhi
Yes-associated protein （YAP）蛋白在许多实体瘤中起致瘤因子的作用，但在乳腺癌中的情况尚存争议。在这里，我们将分析其在乳腺癌中的地位。研究了110例原发性乳腺癌及其配对的局部复发肿瘤中YAP的表达。收集和分析年龄、组织学分级、激素状态、淋巴结和HER2状态等临床病理资料。46.4%（51/110）的乳腺癌原发组织中YAP总表达阳性，显著高于复发组织（10.9%,P < 0.05）。YAP总蛋白在原发性乳腺癌组织中的表达与肿瘤大小呈正相关，尤其是在三阴性乳腺癌（TNBC）亚型中（P < 0.05）。原发性肿瘤中较高的YAP总表达或核表达与TNBC患者较差的无病生存相关（P < 0.05）。在多变量模型中，核YAP表达是TNBC的独立预后因素。高总或核YAP表达预示着TNBC患者预后不良。它可能是未来TNBC的治疗靶点。(C) 2019 Elsevier Inc.版权所有。
Yes-associated protein (YAP) protein acts as tumorigenic factor in many solid tumors, but the situation in breast cancer is under debate. Here, we would analyze its status in breast cancer. YAP expression in the 110 primary breast cancer and their paired local recurrent tumors was investigated. Clinicopathologic data for age, histologic grading, hormone status, lymph nodes and HER2 status were also gathered and analyzed. 46.4% (51/110) primary breast cancer tissues were positive for total YAP expression which was significantly higher than that in the recurrent tissues (10.9%; P < 0.05). The expression of total YAP protein in the primary breast cancer tissues was positively associated with the tumor size, especially in triple negative breast cancer (TNBC) subtype (P < 0.05). Higher total or nuclear YAP expression in the primary tumor was correlated with poor disease-free survival among patients with TNBC (P < 0.05). In the multivariate models, nuclear YAP expression was an independently prognostic factor in TNBC. High total or nuclear YAP expression predicts poor prognosis among patients with TNBC. It might be a therapeutic target for TNBC in the future. (C) 2019 Elsevier Inc. All rights reserved.