Therapeutic neuroprotective agents for amyotrophic lateral sclerosis.
Therapeutic neuroprotective agents for amyotrophic lateral sclerosis.
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DOI：
10.1007/s00018-013-1415-0
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发表时间：
2013-12
影响因子：
8
通讯作者：
Wang, Xin
中科院分区：
文献类型：
--
作者：
Pandya, Rachna S.;Zhu, Haining;Li, Wei;Bowser, Robert;Friedlander, Robert M.;Wang, Xin
Amyotrophic lateral sclerosis (ALS) is a fatal chronic neurodegenerative disease whose hallmark is proteinaceous, ubiquitinated, cytoplasmic inclusions in motor neurons and surrounding cells. Multiple mechanisms proposed as responsible for ALS pathogenesis include dysfunction of protein degradation, glutamate excitotoxicity, mitochondrial dysfunction, apoptosis, oxidative stress, and inflammation. It is therefore essential to gain a better understanding of the underlying disease etiology and search for neuroprotective agents that might delay disease onset, slow progression, prolong survival, and ultimately reduce the burden of disease. Because riluzole, the only Food and Drug Administration (FDA)-approved treatment, prolongs the ALS patient’s life by only 3 months, new therapeutic agents are urgently needed. In this review, we focus on studies of various small pharmacological compounds targeting the proposed pathogenic mechanisms of ALS and discuss their impact on disease progression.
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锂与Riluzole结合治疗肌萎缩性侧面硬化症的安全性和功效：一项随机，双盲，安慰剂对照试验。
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Cudkowicz, Merit
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通讯作者：
Chiu, Chi-Tso
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作者：
Bennett, EJ;Bence, NF;Kopito, RR
通讯作者：
Kopito, RR