Ipsilesional spatial bias after a focal cerebral infarction in the medial agranular cortex: A mouse model of unilateral spatial neglect
Ipsilesional spatial bias after a focal cerebral infarction in the medial agranular cortex: A mouse model of unilateral spatial neglect
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DOI：
10.1016/j.bbr.2020.113097
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发表时间：
2021-01-02
影响因子：
2.7
通讯作者：
Kohno, Yutaka
中科院分区：
文献类型：
--
作者：
Ishii, Daisuke;Osaki, Hironobu;Kohno, Yutaka
单侧空间忽略是脑损伤后发生的一种高级脑功能障碍，如中风、创伤性脑损伤、脑肿瘤和外科手术等，并导致不能注意或响应呈现给损伤的大脑半球对侧的刺激。由于这种情况下的患者往往有其他症状，由于存在几个大脑病变，这是很难评估的恢复机制和单侧空间忽略的训练效果。本研究通过建立单侧空间忽略小鼠模型，探讨病灶大小是否与同病灶空间偏差的严重程度及恢复过程有关。通过光血栓法在小鼠的右内侧无颗粒皮质（AGm）中诱导局灶性梗死。诱发脑梗死后，连续9天评估同病灶空间偏倚。主要发现如下：（1）AGm的单侧局部梗死导致内部指导决策过程中的同侧偏倚;（2）病变大小与损伤程度相关，而不是病变部位的轻微差异;（3）AGm前部病变的小鼠恢复率较低。这些研究结果表明，从同病灶的空间偏见的恢复需要在前AGM的神经可塑性。这种同病灶空间偏差的条件性小鼠模型可用于开发人类单侧空间忽视的有效治疗方法。
Unilateral spatial neglect is a disorder of higher brain function that occurs after a brain injury, such as stroke, traumatic brain injury, brain tumor, and surgical procedures etc., and leads to failure to attend or respond to stimuli presented to the side contralateral to the lesioned cerebral hemisphere. Because patients with this condition often have other symptoms due to the presence of several brain lesions, it is difficult to evaluate the recovery mechanisms and effect of training on unilateral spatial neglect. In this study, a mouse model of unilateral spatial neglect was created to investigate whether the size of the lesion is related to the severity of ipsilesional spatial bias and the recovery process. Focal infarction was induced in the right medial agranular cortex (AGm) of mice via photothrombosis. After induction of cerebral infarction, ipsilesional spatial bias was evaluated for 9 consecutive days. The major findings were as follows: (1) unilateral local infarction of the AGm resulted in ipsilateral bias during internally guided decision-making; (2) the lesion size was correlated with the degree of impairment rather than slight differences in the lesion site; and (3) mice with anterior AGm lesions experienced lower recovery rates. These findings suggest that recovery from ipsilesional spatial bias requires neural plasticity within the anterior AGm. This conditional mouse model of ipsilesional spatial bias may be used to develop effective treatments for unilateral spatial neglect in humans.