Epidermal keratinocytes: regulation of multiple cell phenotypes by multiple protein kinase C isoforms
Epidermal keratinocytes: regulation of multiple cell phenotypes by multiple protein kinase C isoforms
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DOI：
10.1016/j.biocel.2003.12.004
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发表时间：
2004-07-01
影响因子：
4
通讯作者：
Denning, MF
中科院分区：
文献类型：
--
作者：
Denning, MF
鳞状细胞形成表皮的最外层，尽管它们容易从组织中被丢弃，但它们在角质层中起到重要的水屏障功能。角质形成细胞或鳞状角质形成细胞的产生涉及复杂的多步骤分化过程，其确保维持表皮的适当物理和免疫屏障功能。角质形成细胞终末分化的调控受到大量信号通路的影响。本文就蛋白激酶C（PKC）家族在正常角质形成细胞分化中的作用及其与皮肤病特别是皮肤癌的关系作一综述。(C)2004爱思唯尔有限公司保留所有权利。
Squamous cells form the outermost layers of the epidermis, and though they are readily discarded from the tissue, they serve a vital water barrier function while in the stratum corneum. The generation of cornified or squamous keratinocytes involves a complex, multi-step differentiation process that insures the proper physical and immunological barrier functions of the epidermis are maintained. The regulation of keratinocyte terminal differentiation is influenced by a large number of signaling pathways. This article will review some recent findings regarding the roles of the protein kinase C (PKC) family in normal keratinocyte differentiation, as well as their involvement in skin diseases, especially skin cancer. (C) 2004 Elsevier Ltd. All rights reserved.