Direct localisation of the human pedunculopontine nucleus using MRI: a coordinate and fibre-tracking study
Direct localisation of the human pedunculopontine nucleus using MRI: a coordinate and fibre-tracking study
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使用 MRI 直接定位人类脚桥核：坐标和纤维跟踪研究
DOI：
10.1007/s00330-017-5299-5
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发表时间：
2018-09-01
影响因子：
5.9
通讯作者：
Zhuo, Yan
中科院分区：
文献类型：
--
作者：
Cong, Fei;Wang, Jia-Wei;Zhuo, Yan
使用 MRI 对帕金森病的深部脑刺激 (DBS) 靶点桥脚被盖核 (PPN) 进行成像，并获得经过验证的结果。本研究在 7-T 超高场 MRI 系统上使用高分辨率和增强灰白质对比度的 MP2RAGE 序列对 PPN 进行成像，并在 3-T MRI 系统上使用扩散谱成像方法来重建 PPN 周围的主要纤维系统。相对于 7-T 图像上的第三和第四脑室标志测量两侧 PPN 头端和尾端的坐标。PPN 的边界被勾画出来，并显示出与以前的组织学工作一致的形态。 PPN 周围的主要纤维被重建。极坐标结果结合纤维空间关系验证了成像结果。提供了使用MRI直接定位PPN的实用协议；通过相对于两个心室标志定位其极点并检查其与周围纤维系统的空间关系，可以获得并验证 PPN 的位置和形态。该技术可用于临床，在 DBS 手术前以更精确、可靠的方式定义 PPN 的边界，以更精确、可靠的方式治疗帕金森病。a欧元 综合信息有助于将 PPN 定位为 PD 患者的 DBS 目标 a欧元 在 7 T 下扫描 PPN，并根据不同的心室标志测量其坐标 a欧元 使用扩散频谱成像重建 PPN 周围的主要纤维。
To image the pedunculopontine tegmental nucleus (PPN), a deep brain stimulation (DBS) target for Parkinson disease, using MRI with validated results.This study used the MP2RAGE sequence with high resolution and enhanced grey-white matter contrast on a 7-T ultra-high-field MRI system to image the PPN as well as a diffusion spectrum imaging method on a 3-T MRI system to reconstruct the main fibre systems surrounding the PPN. The coordinates of the rostral and caudal PPN poles of both sides were measured in relation to the third and fourth ventricular landmarks on the 7-T image.The boundary of the PPN was delineated, and showed morphology consistent with previous histological works. The main fibres around the PPN were reconstructed. The pole coordinate results combined with the fibre spatial relationships validate the imaging results.A practical protocol is provided to directly localise the PPN using MRI; the position and morphology of the PPN can be obtained and validated by locating its poles relative to two ventricular landmarks and by inspecting its spatial relationship with the surrounding fibre systems. This technique can be potentially used in clinics to define the boundary of the PPN before DBS surgery for treatment of Parkinson disease in a more precise and reliable manner.aEuro cent Combined information helps localise the PPN as a DBS target for PD patientsaEuro cent Scan the PPN at 7 T and measure its coordinates against different ventricular landmarksaEuro cent Reconstruct the main fibres around the PPN using diffusion spectrum imaging.