Compartmentalization of Cerebral Cortical Germinal Zones in a Lissencephalic Primate and Gyrencephalic Rodent
Compartmentalization of Cerebral Cortical Germinal Zones in a Lissencephalic Primate and Gyrencephalic Rodent
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DOI：
10.1093/cercor/bhr312
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发表时间：
2012-02-01
期刊：
影响因子：
3.7
通讯作者：
Molnar, Zoltan
中科院分区：
文献类型：
--
作者：
Garcia-Moreno, Fernando;Vasistha, Navneet A.;Molnar, Zoltan
先前对猕猴和人类皮层的研究发现了细胞结构上不同的生发区；心室区：内室下区（ISVZ）和外室下区（OSVZ）。迄今为止，OSVZ只在脑回畸形的大脑中被描述过，它与ISVZ被一层内部纤维层分开，被认为是触发新皮层神经发生增加的里程碑。然而，这一观察结果只在少数物种中进行了评估，没有确定不同的祖先种群。我们研究了亚马逊啮齿动物刺鼠（Dasyprocta agouti）和狨猴（Callithrix jacchus），以进一步了解祖细胞区隔化、各种皮质祖细胞比例和皮质折叠程度之间的关系。我们发现两个物种在妊娠中期OSVZ和ISVZ之间存在类似的细胞结构差异。在狨猴中，我们量化了脑室和腹室分裂，并观察到与先前描述的人类和雪貂大脑相似的比例。妊娠中期无脑狨猴的放射状胶质细胞、中间祖细胞和外放射状胶质细胞（oRG）群的比例与脑回畸形人或雪貂相似。我们的研究结果表明，SVZ的细胞结构细分是一种进化趋势，而不是灵长类动物的特有特征，并且无论皮质折叠如何，都可以看到大量的oRG群体。
Previous studies of macaque and human cortices identified cytoarchitectonically distinct germinal zones; the ventricular zone inner subventricular zone (ISVZ), and outer subventricular zone (OSVZ). To date, the OSVZ has only been described in gyrencephalic brains, separated from the ISVZ by an inner fiber layer and considered a milestone that triggered increased neocortical neurogenesis. However, this observation has only been assessed in a handful of species without the identification of the different progenitor populations. We examined the Amazonian rodent agouti (Dasyprocta agouti) and the marmoset monkey (Callithrix jacchus) to further understand relationships among progenitor compartmentalization, proportions of various cortical progenitors, and degree of cortical folding. We identified a similar cytoarchitectonic distinction between the OSVZ and ISVZ at midgestation in both species. In the marmoset, we quantified the ventricular and abventricular divisions and observed similar proportions as previously described for the human and ferret brains. The proportions of radial glia, intermediate progenitors, and outer radial glial cell (oRG) populations were similar in midgestation lissencephalic marmoset as in gyrencephalic human or ferret. Our findings suggest that cytoarchitectonic subdivisions of SVZ are an evolutionary trend and not a primate specific feature, and a large population of oRG can be seen regardless of cortical folding.