Modeling dermal exposure--an illustration for spray painting applications.
Modeling dermal exposure--an illustration for spray painting applications.
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皮肤暴露建模——喷漆应用示例。
DOI：
10.1080/15459620600854367
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发表时间：
2006
影响因子：
2
通讯作者：
Nylander-French,LeenaA
中科院分区：
文献类型：
--
作者：
Flynn,MichaelR;Koto,Yoshi;Fent,Kenneth;Nylander-French,LeenaA
本文提出了一个概念，数学模型的皮肤暴露造成的气溶胶沉积在人前臂的头发。该模型适用于接触的情况下，皮肤沉积气溶胶的影响，拦截和扩散机制。该模型采用过滤理论，单纤维效率方程，并修改潜在的气流近似。结果扩展，使用以前发表的结果，应用到皮肤沉积在前臂上喷漆。在10 cm 2胶带条上收集的1，6-二异氰酸酯的平均（N = 8）预测皮肤沉积为108.9（± 70.3）pmol，而现场测量表明平均每条为168.6（± 82.0）pmol。相应的测量平均皮肤通量为3.63 pg/cm 2 s（± 1.34）;预测值为2.24 pg/cm 2 s（± 1.25）。这项研究呼吁人们注意体毛对于建模和测量皮肤暴露的重要性。
This article presents a conceptual, mathematical model of dermal exposure resulting from aerosol deposition on human forearm hair. The model is applicable to exposure scenarios where dermal deposition is governed by aerosol impaction, interception, and diffusion mechanisms. The model employs filtration theory, single fiber efficiency equations, and a modified potential airflow approximation. The results are extended, using previously published results, for application to dermal deposition on the forearm during spray painting. The average (N = 8) predicted dermal deposition of 1,6-hexamethylene diisocyanate as collected on a 10-cm2tape strip is 108.9 (± 70.3) pmol, whereas field measurements indicated an average of 168.6 (± 82.0) pmol per strip. The corresponding measured average dermal flux was 3.63 pg/cm2s (± 1.34); the prediction was 2.24 pg/cm2sec (± 1.25). The study calls attention to the importance of body hair both for modeling and measuring dermal exposures.