Sex differences in spatial and non-spatial Y-maze performance after chronic stress
Sex differences in spatial and non-spatial Y-maze performance after chronic stress
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DOI：
10.1016/s1074-7427(02)00018-7
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发表时间：
2003-01-01
影响因子：
2.7
通讯作者：
Ferayorni, A
中科院分区：
文献类型：
--
作者：
Conrad, CD;Grote, KA;Ferayorni, A
已知慢性束缚可改变雄性大鼠海马CA 3区树突形态和空间记忆。本研究探讨是否雌性大鼠，表现出不同的解剖适应慢性压力比男性，也会表现出空间记忆障碍。将雄性和雌性Sprague-Dawley大鼠限制6小时/天，持续21天，这是先前证明导致海马CA 3树突萎缩的时间范围。在最后一次束缚后的第二天，在Y迷宫上测试大鼠，这是一种可用于评估空间记忆的习惯化任务。慢性应激损害Y-迷宫的性能在两种性别，而不影响运动水平的测量总臂条目在第一分钟。然而，Y-迷宫的表现，强调女性改善2-5分钟时，长期强调男性继续显示Y-迷宫性能差。增强的Y-迷宫性能的长期强调女性发生时，总臂条目较高的条目相比，由男性。因此，总臂条目和空间记忆之间的相关性进行I和2-5分钟。在第一分钟时，控制女性表现出功能性空间记忆，女性控制与最低的运动水平表现出最好的性能。应激雌性动物的相关性并不显著，任何组在2-5分钟内的相关性也不显著。总体而言，这些结果显示了对慢性应激反应的重要性别差异，女性表现出从Y型迷宫性能缺陷中快速恢复的能力。(C)2002 Elsevier Science（美国）。All rights reserved.
Chronic restraint is known to alter hippocampal CA3 dendritic morphology and spatial memory in male rats. The present study examined whether female rats, which exhibit different anatomical adaptations to chronic stress than those of males, would also show spatial memory impairments. Male and female Sprague-Dawley rats were restrained for 6 h/day for 21 days, a time frame previously demonstrated to cause hippocampal CA3 dendritic atrophy. The day after the last restraint session, rats were tested on a Y-maze, a habituation task that can be used to assess spatial memory. Chronic stress impaired Y-maze performance in both sexes without affecting levels of locomotion as measured by total arm entries in the first minute. However, Y-maze performance of stressed females improved in 2-5 min when chronically stressed males continued to show poor Y-maze performance. The enhanced Y-maze performance of chronically stressed females occurred when total arm entries were higher compared to the entries made by males. Therefore, correlations were performed between total arm entries and spatial memory in I and 2-5 min. In the first minute when control females demonstrated functional spatial memory, female controls with the lowest locomotor levels exhibited the best performance. The correlations for stressed females were not significant, and neither were the correlations for any group in 2-5 min. Overall, these results show important sex differences in response to chronic stress with females exhibiting an ability to recover quickly from deficits in Y-maze performance. (C) 2002 Elsevier Science (USA). All rights reserved.