Alcohol consumption and cancers of hormone-related organs in females.
Alcohol consumption and cancers of hormone-related organs in females.
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女性饮酒与激素相关器官的癌症。
DOI：
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发表时间：
1989
影响因子：
2.4
通讯作者：
Chikahiro Terao
中科院分区：
文献类型：
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作者：
Ikuko Kato;Suketami Tominaga;Chikahiro Terao
一项病例对照研究调查了饮酒与乳腺癌、子宫体癌和卵巢癌之间的关系，该研究涉及 1,740 例乳腺癌、239 例子宫体癌、417 例卵巢癌和 8,920 例对照，其中对照来自 1980-1986 年日本爱知癌症登记处发现的其他癌症部位。与不饮酒者相比，每日饮酒者的年龄调整相对风险（RR）显着增加，乳腺癌（RR = 1.36，95%置信区间（CI）1.04-1.78），子宫体癌的年龄调整相对风险（RR = 0.44，95% CI 0.15-1.38）显着降低（RR = 0.44，95% CI 0.15-1.38），卵巢癌显着降低（RR = 1.36，95%置信区间（CI）1.04-1.78）。 0.38，95% CI 0.16-0.90）。在 50 岁及以上的年龄范围内，与每日饮酒相关的乳腺癌风险明显增加，其中啤酒的风险最高。控制年龄、居住地、婚姻状况、职业、吸烟习惯和乳腺癌家族史的多变量分析并未显着改变每日饮酒者的 RR。尽管该研究存在一些局限性，但结果与其他国家之前的研究结果一致，表明饮酒可能会增加日本女性患乳腺癌的风险，就像其他地方的饮酒一样。本研究还表明，饮酒与女性其他激素相关器官患癌症的风险升高无关，但可能与卵巢癌风险降低有关。
The relations between alcohol consumption and cancers of the breast, corpus uteri and ovary were investigated in a case-control study involving 1,740 cases of breast cancer, 239 cases of cancer of the corpus uteri, 417 cases of ovarian cancer and 8,920 controls with other cancer sites identified from the Aichi Cancer Registry, Japan 1980-1986. The age-adjusted relative risk (RR) of daily alcohol drinkers compared to non-drinkers was significantly increased for breast cancer (RR = 1.36, 95% confidence interval (CI) 1.04-1.78), that for cancer of the corpus uteri was lowered insignificantly (RR = 0.44, 95% CI 0.15-1.38) and that for ovarian cancer was significantly lowered (RR = 0.38, 95% CI 0.16-0.90). The increase in the risk of breast cancer associated with daily alcohol drinking was evident in the age range 50 and over, the risk specified by type of alcoholic beverage being highest for beer. Multivariate analyses controlled for age, residence, marital status, occupation, smoking habit and family history of breast cancer did not materially change the RRs of daily alcohol drinkers. Despite the several limitations of the study, the results were consistent with those of previous studies from other countries, suggesting that alcohol consumption may contribute to the risk of breast cancer in Japanese woman, as it dose elsewhere. The present study also suggested alcohol consumption not to be associated with elevated risks of cancer in other hormone-related organs in females, and possibly to be associated with a decreased risk of ovarian cancer.