Live Attenuated Human Salmonella Vaccine Candidates: Tracking the Pathogen in Natural Infection and Stimulation of Host Immunity.
Live Attenuated Human Salmonella Vaccine Candidates: Tracking the Pathogen in Natural Infection and Stimulation of Host Immunity.
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DOI：
10.1128/ecosalplus.esp-0010-2016
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发表时间：
2016-11
期刊：
影响因子：
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通讯作者：
Pasetti MF
中科院分区：
文献类型：
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作者：
Galen JE;Buskirk AD;Tennant SM;Pasetti MF
沙门氏菌病由沙门氏菌属成员引起，在全球动物和人类中造成相当大的发病率和死亡率。在本文中，我们将讨论伤寒沙门氏菌和鼠伤寒沙门氏菌的发病机制，重点是人类沙门氏菌感染。我们将追踪沙门氏菌通过人体的路径，包括宿主的进入部位，受影响的组织和器官，以及涉及致病和刺激宿主免疫的机制。仔细考虑疾病的自然进展为合理设计和开发减毒口服活疫苗提供了重要背景。考虑到这一点，我们将介绍一系列已在临床试验中成功测试并证明既安全又具有高度免疫原性的减毒口服活疫苗。本综述中总结的减毒策略为进一步开发针对其他沙门氏菌的减毒疫苗提供了重要的见解，这些减毒疫苗目前还没有活的口服候选疫苗。
Salmonellosis, caused by members of the genus Salmonella, is responsible for considerable global morbidity and mortality, in both animals and humans. In this review, we will discuss the pathogenesis of S. Typhi and S. Typhimurium, focusing on human Salmonella infections. We will trace the path of Salmonella through the body, including host entry sites, tissues and organs affected, and mechanisms involved in both pathogenesis and stimulation of host immunity. Careful consideration of the natural progression of disease provides an important context in which attenuated live oral vaccines can be rationally designed and developed. With this in mind, we will describe a series of attenuated live oral vaccines that have been successfully tested in clinical trials and demonstrated to be both safe and highly immunogenic. The attenuation strategies summarized in this review offer important insights into further development of attenuated vaccines against other Salmonella for which live oral candidates are currently unavailable.