Newly Developed Novel Ultrasound Technique, Defect Reperfusion Ultrasound Imaging, Using Sonazoid in the Management of Hepatocellular Carcinoma
Newly Developed Novel Ultrasound Technique, Defect Reperfusion Ultrasound Imaging, Using Sonazoid in the Management of Hepatocellular Carcinoma
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DOI：
10.1159/000315229
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发表时间：
2010-01-01
期刊：
影响因子：
3.5
通讯作者：
Maekawa, Kiyoshi
中科院分区：
文献类型：
--
作者：
Kudo, Masatoshi;Hatanaka, Kinuyo;Maekawa, Kiyoshi
本研究的目的是阐明使用索那唑的缺损性再灌注超声(US)成像在肝细胞癌(HCC)治疗中的作用。对33个B超不能显示但动态CT显示的肝细胞癌射频消融(RFA)后局部复发结节和33个肝癌结节进行索那唑的缺损性再灌注超声成像研究。此外，在262例连续的肝硬变患者中，使用Kupffer相Sonazid增强超声结合缺损性再灌注超声成像对肝细胞癌进行筛查。结果，33个超声未检出的肝细胞癌结节和34个局部复发的肝细胞癌结节被索那唑增强超声结合缺损性再灌注成像成功证实。随后，在Sonazid增强的US指导下，成功地对所有67个肝癌结节进行了RFA。经Kupffer时相监测和缺损区再灌注超声显像证实为小肝癌7例。总之，缺损性再灌注超声成像在描述和确认超声未检出的肝细胞癌以及监测肝硬变患者的肝细胞癌方面是非常有用的。版权所有(C)2010 S.Karger AG，巴塞尔
The aim of this study is to clarify the usefulness of defect reperfusion ultrasound (US) imaging using Sonazoid in the management of hepatocellular carcinoma (HCC). A total of 33 HCC nodules and 34 local recurring nodules after radio-frequency ablation (RFA), which could not be identified by B-mode US but were depicted by dynamic CT, were studied by defect reperfusion US imaging with Sonazoid. In addition, Kupffer phase Sonazoid-enhanced US in combination with defect reperfusion US imaging were used for screening HCC in 262 consecutive cirrhotic patients. As a result, 33 US undetectable HCC nodules and 34 local recurring HCC nodules were successfully confirmed by Sonazoid-enhanced US with defect reperfusion imaging. Subsequently, RFA was successfully performed in all of 67 HCC nodules with a Sonazoid-enhanced US guidance. A total of 7 small HCCs were depicted and confirmed as HCCs by Kupffer phase surveillance and defect reperfusion US imaging. In conclusion, defect reperfusion US imaging is extremely useful in the depiction and confirmation of US undetectable HCCs as well as in the surveillance of HCC in cirrhotic patients. Copyright (C) 2010 S. Karger AG, Basel