Single caudate neurons encode temporally discounted value for formulating motivation for action.
Single caudate neurons encode temporally discounted value for formulating motivation for action.
复制标题
单尾状神经元编码时间贴现值，形成行动动机。
DOI：
10.7554/elife.61248
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发表时间：
2021-07-30
期刊：
影响因子：
7.7
通讯作者：
Minamimoto T
中科院分区：
文献类型：
--
作者：
Hori Y;Mimura K;Nagai Y;Fujimoto A;Oyama K;Kikuchi E;Inoue KI;Takada M;Suhara T;Richmond BJ;Minamimoto T
“时间折扣”一词既描述了选择偏好，也描述了延迟奖励的动机。在这里，我们展示了灵长类尾状头（dCDh）背侧的神经元活动发出了计算延迟奖励动机所需的时间折扣值的信号。猕猴完成了一项工具性任务，其中视觉线索表明即将到来的大小和奖励前的延迟时间。单个dCDh神经元代表时间贴现值，不反映动物生理状态的变化。双侧dCDh的药理学或化学发生失活显著扭曲了基于奖励大小和延迟的正常任务表现，但对不同奖励大小的无延迟任务表现没有影响。这些结果表明，dCDh参与编码对动机至关重要的综合多维信息。
The term ‘temporal discounting’ describes both choice preferences and motivation for delayed rewards. Here we show that neuronal activity in the dorsal part of the primate caudate head (dCDh) signals the temporally discounted value needed to compute the motivation for delayed rewards. Macaque monkeys performed an instrumental task, in which visual cues indicated the forthcoming size and delay duration before reward. Single dCDh neurons represented the temporally discounted value without reflecting changes in the animal’s physiological state. Bilateral pharmacological or chemogenetic inactivation of dCDh markedly distorted the normal task performance based on the integration of reward size and delay, but did not affect the task performance for different reward sizes without delay. These results suggest that dCDh is involved in encoding the integrated multi-dimensional information critical for motivation.