The expression of the SWI/SNF ATPase subunits BRG1 and BRM in normal human tissues
The expression of the SWI/SNF ATPase subunits BRG1 and BRM in normal human tissues
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DOI：
10.1097/00129039-200503000-00011
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发表时间：
2005-03-01
影响因子：
1.6
通讯作者：
Funkhouser, WK
中科院分区：
文献类型：
--
作者：
Reisman, DN;Sciarrotta, J;Funkhouser, WK
SWI/SNF是一种在基因调控、细胞因子反应、肿瘤发生、分化和发育中具有重要作用的染色质重塑复合物。由于众多信号通路需要SWI/SNF，预计SWI/SNF功能缺失会对细胞表型产生影响。SWI/SNF的ATP酶亚基BRG1和BRM已被证实在一部分人类癌细胞系和原发性人类癌症中缺失，并且可能代表肿瘤抑制蛋白。为了更好地理解这些蛋白的生物学特性，作者检测了BRG1和BRM在多种正常组织中的表达模式。BRG1主要在不断增殖或自我更新的细胞类型中表达；相比之下，BRM优先在脑、肝、纤维肌性间质和内皮细胞类型中表达，这些细胞类型并不经常进行增殖或自我更新。这种差异表达表明这些蛋白在人体组织中具有不同的功能。
SWI/SNF is a chromatin-remodeling complex important in gene regulation, cytokine responses, tumorigenesis, differentiation, and development. As a multitude of signaling pathways require SWI/SNF, loss of SWI/SNF function is expected to have an impact on cellular phenotypes. The SWI/SNF ATPase subunits, BRG1 and BRM, have been shown to be lost in a subset of human cancer cell lines and human primary cancers and may represent tumor suppressor proteins. To better understand the biology of these proteins, the authors examined the expression pattern of BRG1 and BRM in a variety of normal tissues. BRG1 expression was predominantly seen in cell types that constantly undergo proliferation or self-renewal; in contrast, BRM was preferentially expressed in brain, liver, fibromuscular stroma, and endothelial cell types, cell types not constantly engaged in proliferation or self-renewal. This differential expression suggests that these proteins serve distinct functions in human tissues.