CD4 T-cell hyperactivation and susceptibility to cell death determine poor CD4 T-cell recovery during suppressive HAART
CD4 T-cell hyperactivation and susceptibility to cell death determine poor CD4 T-cell recovery during suppressive HAART
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DOI：
10.1097/qad.0b013e328337b957
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发表时间：
2010-04-24
期刊：
影响因子：
3.8
通讯作者：
Blanco, Julia
中科院分区：
文献类型：
--
作者：
Massanella, Marta;Negredo, Eugenia;Blanco, Julia
背景：在一些接受HAART治疗的HIV感染患者中，未能提高CD4T细胞计数，并获得满意的病毒学应答，与CD4T细胞产量低、周转率高和死亡有关。然而，这些因素的相对贡献仍然不清楚，强烈限制了对这些患者合适的治疗策略的定义。方法：设计了一项横断面研究，以评估胸腺活动、微生物易位、细胞激活和死亡对CD4T细胞恢复的贡献。我们纳入了230名接受抑制性HAART的HIV感染者(2年)；其中95人被认为是不协调的(CD4T细胞计数
Background: The failure to increase CD4 T-cell counts in some HAART-treated HIV-infected patients with satisfactory virological responses has been related to low CD4 T-cell production, high turnover and death. However, the relative contribution of these factors is still unclear, strongly limiting the definition of appropriate therapeutic strategies for these patients.Methods: A cross-sectional study was designed to evaluate the contribution of thymic activity, microbial translocation, cellular activation and death to CD4 T-cell recovery. We included 230 HIV-infected individuals on suppressive HAART (>2 years); 95 of them were considered 'discordant' (CD4 T-cell count