Interplay between metalloproteinases and cell signalling in blood brain barrier integrity.
Interplay between metalloproteinases and cell signalling in blood brain barrier integrity.
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DOI：
10.14670/hh-18-003
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发表时间：
2018-05
影响因子：
2
通讯作者：
Irene Pla-Navarro;D. Bevan;M. Hajihosseini;Martin Lee;J. Gavrilovic
中科院分区：
文献类型：
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作者：
Irene Pla-Navarro;D. Bevan;M. Hajihosseini;Martin Lee;J. Gavrilovic
血脑屏障 (BBB) 是一个高度专业化的界面，将中枢神经系统 (CNS) 与循环血液分开。 BBB 失调是炎症等病理状况的一个关键早期事件，其中 BBB 分解促进了活化的白细胞进入 CNS。金属蛋白酶 (MP) 的 metzincin 家族是 BBB 通透性的主要贡献者之一，因为它们会裂解内皮细胞-细胞接触和底层基底层成分。然而，国会议员调节血脑屏障完整性的机制尚未完全阐明。本综述的目的是概述 MP 在神经炎症背景下调节 BBB 的途径。
The Blood-Brain Barrier (BBB) is a highly specialised interface separating the Central Nervous System (CNS) from circulating blood. Dysregulation of the BBB is a key early event in pathological conditions such as inflammation, in which the entry of activated leukocytes into the CNS is facilitated by BBB breakdown. The metzincin family of metalloproteinases (MPs) is one of the major contributors to BBB permeability as they cleave endothelial cell-cell contacts and underlying basal lamina components. However, the mechanisms by which MPs regulate BBB integrity has not yet been fully elucidated. The aim of this review is to provide an overview of pathways by which MPs could regulate the BBB in the context of neuroinflammation.