Gut mucosal microbiome across stages of colorectal carcinogenesis.
Gut mucosal microbiome across stages of colorectal carcinogenesis.
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结直肠癌发生各个阶段的肠道粘膜微生物组
DOI：
10.1038/ncomms9727
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发表时间：
2015-10-30
影响因子：
16.6
通讯作者：
Sung JJ
中科院分区：
文献类型：
--
作者：
Nakatsu G;Li X;Zhou H;Sheng J;Wong SH;Wu WK;Ng SC;Tsoi H;Dong Y;Zhang N;He Y;Kang Q;Cao L;Wang K;Zhang J;Liang Q;Yu J;Sung JJ
肠道微生物生态失调有助于结直肠癌（CRC）的发展。在这里，我们对结直肠肿瘤发生的不同阶段人类肠道粘膜的微生物群落进行了分类。我们分析了47对腺瘤和腺瘤邻近粘膜样本、52对癌和癌邻近粘膜样本以及61名健康对照者的肠道黏膜微生物组。相对丰度分布的概率划分表明，以口腔微生物组成员为主的元群落主要与CRC相关。配对样本的分析显示病变和邻近粘膜之间的群落结构存在差异。细菌分类群的相关性表明腺瘤中生态失调的早期迹象，而共排他关系随后在癌症中更为常见。我们通过与先前发表的两个数据集进行比较，验证了crc相关微生物组的这些变化。我们的研究结果表明，一个分类学上定义的微生物联合体与CRC的发展有关。
Gut microbial dysbiosis contributes to the development of colorectal cancer (CRC). Here we catalogue the microbial communities in human gut mucosae at different stages of colorectal tumorigenesis. We analyse the gut mucosal microbiome of 47 paired samples of adenoma and adenoma-adjacent mucosae, 52 paired samples of carcinoma and carcinoma-adjacent mucosae and 61 healthy controls. Probabilistic partitioning of relative abundance profiles reveals that a metacommunity predominated by members of the oral microbiome is primarily associated with CRC. Analysis of paired samples shows differences in community configurations between lesions and the adjacent mucosae. Correlations of bacterial taxa indicate early signs of dysbiosis in adenoma, and co-exclusive relationships are subsequently more common in cancer. We validate these alterations in CRC-associated microbiome by comparison with two previously published data sets. Our results suggest that a taxonomically defined microbial consortium is implicated in the development of CRC.