Experimental demonstration of benchtop x-ray fluorescence computed tomography (XFCT) of gold nanoparticle-loaded objects using lead- and tin-filtered polychromatic cone-beams.
Experimental demonstration of benchtop x-ray fluorescence computed tomography (XFCT) of gold nanoparticle-loaded objects using lead- and tin-filtered polychromatic cone-beams.
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DOI：
10.1088/0031-9155/57/23/n457
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发表时间：
2012-12-07
影响因子：
3.5
通讯作者：
Cho SH
中科院分区：
文献类型：
--
作者：
Jones BL;Manohar N;Reynoso F;Karellas A;Cho SH
本报告提出了第一个实验演示，据我们所知，台式多色锥束X射线荧光计算机断层扫描（XFCT）的空间分布和数量的金纳米粒子（GNP）的同时测定小动物大小的对象。目前的台式实验装置成功地产生了XFCT图像，准确地显示了在3cm直径的塑料体模内含有少量GNP（约0.1 mg）的区域。特别地，当前XFCT设置的性能显著提高（例如，XFCT扫描时间减少至少3倍）。这项研究的结果强烈表明，目前的台式XFCT配置可以通过一些修改（例如部署阵列探测器）变得实用，同时满足常规临床前体内GNP成像的X射线剂量、扫描时间和图像分辨率的现实限制。
This report presents the first experimental demonstration, to our knowledge, of benchtop polychromatic cone-beam x-ray fluorescence computed tomography (XFCT) for a simultaneous determination of the spatial distribution and amount of gold nanoparticles (GNPs) within small-animal-sized objects. The current benchtop experimental setup successfully produced XFCT images accurately showing the regions containing small amount of GNPs (on the order of 0.1 mg) within a 3-cm diameter plastic phantom. In particular, the performance of the current XFCT setup was improved remarkably (e.g., at least a factor of 3 reduction in XFCT scan time) using a tin-filtered polychromatic beam in comparison with a lead-filtered beam. The results of this study strongly suggest the current benchtop XFCT configuration can be made practical with a few modifications such as the deployment of array detectors, while meeting realistic constraints on x-ray dose, scan time, and image resolution for routine pre-clinical in-vivo imaging with GNPs.