Serum folate levels and cognitive performance in the ELSA-Brasil baseline assessment.
Serum folate levels and cognitive performance in the ELSA-Brasil baseline assessment.
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DOI：
10.1590/0004-282x20200074
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发表时间：
2020-11
影响因子：
1.4
通讯作者：
Bensenor IM
中科院分区：
文献类型：
--
作者：
Santos IS;Suemoto CK;ValladÃo-Junior JBR;Liu S;Barreto SM;Fedeli LMG;Lotufo PA;Bensenor IM
大多数分析血清叶酸水平与认知功能之间关系的研究要么将其评估限制在特定的临床情况下，要么不包括中年人，对他们来说，预防认知障碍的策略可能更可行。在巴西成人健康纵向研究（ELSA-Brasil）基线评估中检查血清叶酸水平与认知功能之间的关系。来自4，571名居住在圣保罗州的ELSA巴西参与者的数据进行了分析，年龄在35-74岁之间。认知测验包括词汇表学习、延迟回忆、词汇再认、言语流畅性和连线测验B部分。对于每个测试，计算年龄，性别和教育特定的标准化分数和整体认知分数。使用粗线性回归模型和校正线性回归模型来检查血清叶酸水平与认知测试分数的相关性。在多变量校正模型中，血清叶酸与总体认知评分无关（β=-0.043;最低与最高五分位组的95%置信区间[95%CI]为-0.135至0.050），也与任何认知测试表现无关。在按年龄、性别或使用维生素补充剂分层的亚组中，我们也没有发现血清叶酸和总体认知评分之间的相关性。在这个大样本中，我们没有发现血清叶酸和认知能力之间的显着关联，其特征是食品强化政策的背景下，叶酸缺乏症的发生率较低。以前研究的积极结果可能不适用于食品强化越来越普遍的情况，也不适用于年轻人。
Most studies that analyze the association between serum folate levels and cognitive function either restrict their assessments to specific clinical scenarios or do not include middle-aged individuals, to whom strategies for preventing cognitive impairment may be more feasible. To examine the association between serum folate levels and cognitive function in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) baseline assessment. Data from 4,571 ELSA-Brasil participants who live in the state of São Paulo, aged 35–74 years, were analyzed. The word list learning, delayed recall, word recognition, verbal fluency, and Trail Making Test Part B consisted in the cognitive tests. For each test, age, sex, and education-specific standardized scores and a global cognitive score were calculated. Crude and adjusted linear regression models were used to examine the associations of serum folate levels with cognitive test scores. In multivariable-adjusted models, serum folate was not associated with global cognitive score (β=−0.043; 95% confidence interval [95%CI] −0.135 to 0.050 for lowest vs. highest quintile group), nor with any cognitive test performance. We did not find associations between serum folate and global cognitive scores in subgroups stratified by age, sex, or use of vitamin supplements either. We did not find significant associations between serum folate and cognitive performance in this large sample, which is characterized by a context of food fortification policies and a consequent low frequency of folate deficiency. Positive results from previous studies may not apply to the increasingly common contexts in which food fortification is implemented, or to younger individuals.