Enrolling children with acute lymphoblastic leukaemia on a clinical trial improves event-free survival: a population-based study
Enrolling children with acute lymphoblastic leukaemia on a clinical trial improves event-free survival: a population-based study
复制标题
DOI：
10.1038/bjc.2017.462
复制
发表时间：
2018-03-06
影响因子：
8.8
通讯作者：
Sung, Lillian
中科院分区：
文献类型：
--
作者：
Strahlendorf, Caron;Pole, Jason D.;Sung, Lillian
背景资料：本研究的目的是描述的影响，在诊断的无事件和总生存率在儿科急性淋巴细胞白血病（ALL）使用人口为基础的approach.Methods：我们进行了一项回顾性队列研究，包括新诊断的儿童急性淋巴细胞白血病1至14岁。数据来源是加拿大年轻人癌症（CYP-C）国家儿科癌症人群数据库。我们进行了单变量和多个考克斯比例风险models.Results：有2569名儿童与ALL，1408（54.8%）参加了临床试验在初步诊断。5年无事件生存率为89.8% +/- 0.9 vs 84.1% +/- 1.2。（P
Background: The objectives of this study were to describe the impact of trial enrollment at diagnosis on event-free and overall survival in paediatric acute lymphoblastic leukaemic (ALL) using a population-based approach.Methods: We conducted a retrospective cohort study that included children newly diagnosed with ALL between 1 and 14 years of age. The data source was the Cancer in Young People in Canada (CYP-C) national paediatric cancer population-based database. We conducted univariate and multiple Cox proportional hazards models.Results: There were 2569 children with ALL; 1408 (54.8%) were enrolled on a clinical trial at initial diagnosis. Event-free survival at 5 years was 89.8% +/- 0.9 vs 84.1% +/- 1.2. (P