Indium Tribromide Catalyzed Coupling Reaction of Enol Ethers with Silyl Ketene Imines toward the Synthesis of β,γ-Unsaturated Nitriles.
Indium Tribromide Catalyzed Coupling Reaction of Enol Ethers with Silyl Ketene Imines toward the Synthesis of β,γ-Unsaturated Nitriles.
复制标题
DOI：
10.1002/chem.201503414
复制
发表时间：
2015-12
期刊：
影响因子：
--
通讯作者：
Yoshihiro Nishimoto;T. Nishimura;M. Yasuda
中科院分区：
文献类型：
--
作者：
Yoshihiro Nishimoto;T. Nishimura;M. Yasuda
本文报道了烯醇醚与硅酮亚胺在InBr3和ME3-SIBR催化剂存在下的偶联反应。动力学研究表明，铟催化剂和ME3-SIBR分别加速了催化剂的偶联过程和再生。各种类型的烯醇醚和硅酮亚胺都是适用的。此外，利用这种新的偶联反应实现了维拉帕米的正式合成。
Herein, a coupling reaction of enol ethers with silyl ketene imines in the presence of catalytic amounts of InBr3 and Me3 SiBr is described. Kinetic studies have revealed that an indium catalyst and Me3 SiBr accelerated the coupling process and the regeneration of the catalyst, respectively. Various types of enol ethers and silyl ketene imines are applicable. In addition, a formal synthesis of verapamil was achieved by using this novel coupling reaction.