Mixed micelles made of poly(ethylene glycol)-phosphatidylethanolamine conjugate and D-α-tocopheryl polyethylene glycol 1000 succinate as pharmaceutical nanocarriers for camptothecin
Mixed micelles made of poly(ethylene glycol)-phosphatidylethanolamine conjugate and D-α-tocopheryl polyethylene glycol 1000 succinate as pharmaceutical nanocarriers for camptothecin
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DOI：
10.1016/j.ijpharm.2005.08.026
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发表时间：
2005-12-08
影响因子：
5.8
通讯作者：
Torchilin, VP
中科院分区：
文献类型：
--
作者：
Mu, L;Elbayoumi, TA;Torchilin, VP
以难溶抗癌药物喜树碱(CPT)为载药，制备了聚乙二醇-磷脂酰乙醇胺结合物(PEGPE)与D-生育酚聚乙二醇1000琥珀酸酯(TPGS)的共聚物胶束。混合胶束对CPT的增溶作用比先前所述的单独使用聚乙二醇PE胶束的增溶效果更好。CPT混合胶束在储存和稀释过程中稳定，并牢牢地保持了药物的包封性。CPT混合胶束对多种肿瘤细胞的体外杀伤作用明显高于游离药物。PEG-PE/TPGS混合胶束可以作为药物纳米载体，提高对难溶药物的增溶能力。(C)2005 Elsevier B.V.保留所有权利。
Micelles from the mixture of poly(ethylene glycol)-phosphatidyl ethanolamine conjugate (PEG-PE) and D-alpha-tocopheryl polyetheyene glycol 1000 succinate (TPGS) were prepared loaded with the poorly soluble anticancer drug camptothecin (CPT). The solubilization of CPT by the mixed micelles was more efficient than with earlier described micelles made of PEG-PE alone. CPT-loaded mixed micelles were stable upon storage and dilution and firmly retained the incorporated drug. The cytotoxicity of the CPT-loaded mixed micelles against various cancer cells in vitro was remarkably higher than that of the free drug. PEG-PE/TPGS mixed micelles may serve as pharmaceutical nanocarriers with improved solubilization capacity for poorly soluble drugs. (c) 2005 Elsevier B.V. All rights reserved.