EFFECTS OF ORAL PH ON CIGARETTE-SMOKING
EFFECTS OF ORAL PH ON CIGARETTE-SMOKING
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DOI：
10.1016/0091-3057(78)90045-x
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发表时间：
1978-01-01
影响因子：
3.6
通讯作者：
KLEIMAN, RM
中科院分区：
文献类型：
--
作者：
KOZLOWSKI, LT;KLEIMAN, RM
尼古丁通过口腔粘膜的渗透性先前被证明是口腔中碱度的直接线性函数。通过用Sorensen和McIlvaine缓冲液冲洗，将吸烟者的口腔pH值从5-8控制。随着碱性的增加，香烟的味道被认为更强烈，更苦，在某些情况下，更令人不快;心率略有加快。尼古丁自我给药和血压不受影响。尼古丁的差异吸收和交叉适应的酸味苦味进行了讨论。
Permeability of nicotine across the oral mucosa was previously shown to be a direct linear function of alkalinity in the oral cavity. Oral pH in human cigarette smokers was manipulated from pH 5-8 by rinses with Sorenson''s and McIlvaine''s buffers. As alkalinity increased, cigarette taste was perceived as stronger, more bitter, and, in some cases, more unpleasant; heart-rate accelerated slightly. Nicotine self-administration and blood pressure were not influenced. Differential absorption of nicotine and cross-adaptation of sour to bitter tastes were discussed.