Reconstruction of the 1918 Influenza Virus: Unexpected Rewards from the Past
Reconstruction of the 1918 Influenza Virus: Unexpected Rewards from the Past
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DOI：
10.1128/mbio.00201-12
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发表时间：
2012-09-01
期刊：
影响因子：
6.4
通讯作者：
Wilson, Ian A.
中科院分区：
文献类型：
--
作者：
Taubenberger, Jeffery K.;Baltimore, David;Wilson, Ian A.
1918-1919年的流感大流行造成约5000万人死亡。与大流行相关的异常严重的发病率和死亡率促使医生和科学家分离病原体，但病毒在1918年没有分离出来。1996年，人们有可能从1918年的几名受害者的保存组织中回收并测序保留的流感病毒RNA的高度降解片段。这些病毒RNA序列最终使得1918年病毒的完整重组成为可能，在其受害者死亡后的近世纪，该病毒为流感病毒生物学和发病机制提供了新的见解，并为如何预防和控制未来的大流行病提供了重要信息。
The influenza pandemic of 1918-1919 killed approximately 50 million people. The unusually severe morbidity and mortality associated with the pandemic spurred physicians and scientists to isolate the etiologic agent, but the virus was not isolated in 1918. In 1996, it became possible to recover and sequence highly degraded fragments of influenza viral RNA retained in preserved tissues from several 1918 victims. These viral RNA sequences eventually permitted reconstruction of the complete 1918 virus, which has yielded, almost a century after the deaths of its victims, novel insights into influenza virus biology and pathogenesis and has provided important information about how to prevent and control future pandemics.