The association between the length of the QT interval and mortality in the cardiovascular health study
The association between the length of the QT interval and mortality in the cardiovascular health study
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DOI：
10.1016/j.amjmed.2003.07.014
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发表时间：
2003-12-15
影响因子：
5.9
通讯作者：
Gottdiener, JS
中科院分区：
文献类型：
--
作者：
Robbins, J;Nelson, JC;Gottdiener, JS
目的：QT 间期过长是心律失常事件和猝死的危险因素。中度 QT 延长是否与社区老年患者的临床事件相关尚不确定。方法：我们测量了 5888 名年龄至少 65 岁的男性和女性心血管健康研究参与者的人群样本的 QT 间期。评估了 Bazett 的率校正 QT（QTc，以毫秒为单位）与随后 10 年死亡率之间的关联。我们根据基线时是否存在冠心病状态对参与者进行分层，并根据冠心病危险因素进行调整。结果：QTc 间期较长的参与者的全因死亡率和冠心病死亡率较高。在没有已知冠心病的参与者中，与 QTc 间期为 d450 ms 的参与者相比，QTc 间期 > 450 ms 的参与者全因死亡率（相对风险 [RR] = 1.34；95% 置信区间 [CI]：1.07 至 1.67）和冠心病死亡率（RR = 1.6；95% CI：1.0 至 2.5）的风险增加，应提示进行临床评估，并可能降低冠状动脉事件风险的干预措施。 (C) 2003 年，Excerpta Medica Inc.
PURPOSE: A long QT interval is a risk factor for arrhythmic events and sudden death. Whether moderate QT prolongation is associated with clinical events in community-dwelling elderly patients is uncertain.METHODS: We measured the QT interval in a population-based sample of 5888 men and women at least 65 years of age who were participants in the Cardiovascular Health Study. The association between Bazett's rate-corrected QT (QTc, in ms) and mortality during the subsequent 10 years was evaluated. We stratified participants by the presence or absence of coronary heart disease status at baseline, and adjusted for coronary heart disease risk factors.RESULTS: The rates of all-cause and coronary heart disease mortality were greater in participants with longer QTc intervals. Among participants without known coronary heart disease, those whose QTc interval was >450 ms were at increased risk of all-cause mortality (relative risk [RR] = 1.34; 95% confidence interval [CI]: 1.07 to 1.67) and coronary heart disease mortality (RR = 1.6; 95% CI: 1.0 to 2.5) when compared with participants whose QTc interval was d450 ms should prompt clinical evaluation and possible interventions to reduce the risk of coronary events. (C) 2003 by Excerpta Medica Inc.