Effect of natural killer cells on induced pluripotent stem cell-derived bioartificial cardiac tissue
Effect of natural killer cells on induced pluripotent stem cell-derived bioartificial cardiac tissue
复制标题
自然杀伤细胞对诱导多能干细胞来源的生物人工心脏组织的影响
DOI：
10.1055/s-0034-1367266
复制
发表时间：
2014
影响因子：
1.5
通讯作者：
Kutschka I
中科院分区：
文献类型：
--
作者：
Saito S;Kensah G;Baraki H;Dahlmann J;Haverich A;Hundrieser J;Martin U;Gruh I;Kutschka I
目的：将患者来源的体细胞重编程为多能状态可用于提供自体诱导多能干细胞（iPSC）。然而，在急性心肌梗死（MI）的情况下，更有可能的是同种异体iPSC衍生的心血管细胞将用于重建治疗。因此，详细了解宿主细胞对移植物的免疫反应是必要的。
Objectives: Reprogramming of patient-derived somatic cells into a pluripotent state can be used to provide autologous induced pluripotent stem cells (iPSCs). However, in case of acute myocardial infarction (MI), it is more likely that allogeneic iPSC-derived cardiovascular cells will be used for reconstructive therapies. Therefore, a detailed understanding of immunological reactions of host cells to the transplant is necessary.