Ghrelin and functional dyspepsia.
Ghrelin and functional dyspepsia.
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DOI：
10.1155/2010/548457
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发表时间：
2010-01-01
期刊：
影响因子：
--
通讯作者：
Kangawa, Kenji
中科院分区：
文献类型：
--
作者：
Akamizu, Takashi;Iwakura, Hiroshi;Kangawa, Kenji
大多数消化不良患者没有可识别的病因，从而被诊断为功能性消化不良（FD）。虽然有许多不同的因素影响肠道活动，但神经和内分泌系统的组成部分对正常的肠道功能至关重要。大脑和肠道之间的交流通过直接神经连接或内分泌信号事件发生。Ghrelin是一种由胃产生的肽，影响胃运动/排空和分泌，表明它可能在FD中发挥病理生理作用。FD中的功能异常也可能影响胃中Ghrelin的产生。据报道，FD患者血浆胃饥饿素水平发生改变，与FD症状评分相关。此外，一些患有FD的患者患有厌食症并伴有体重减轻。由于ghrelin增加胃排空和促进进食，ghrelin治疗可能是治疗FD的新方法。
The majority of patients with dyspepsia have no identifiable cause of their disease, leading to a diagnosis of functional dyspepsia (FD). While a number of different factors affect gut activity, components of the nervous and endocrine systems are essential for normal gut function. Communication between the brain and gut occurs via direct neural connections or endocrine signaling events. Ghrelin, a peptide produced by the stomach, affects gastric motility/emptying and secretion, suggesting it may play a pathophysiological role in FD. It is also possible that the functional abnormalities in FD may affect ghrelin production in the stomach. Plasma ghrelin levels are reported to be altered in FD, correlating with FD symptom score. Furthermore, some patients with FD suffer from anorexia with body-weight loss. As ghrelin increases gastric emptying and promotes feeding, ghrelin therapy may be a new approach to the treatment of FD.