NEUROPSYCHOLOGIC CORRELATES OF MRI WHITE-MATTER HYPERINTENSITIES - A STUDY OF 150 NORMAL VOLUNTEERS
NEUROPSYCHOLOGIC CORRELATES OF MRI WHITE-MATTER HYPERINTENSITIES - A STUDY OF 150 NORMAL VOLUNTEERS
复制标题
DOI：
10.1212/wnl.43.12.2490
复制
发表时间：
1993-12-01
期刊：
影响因子：
9.9
通讯作者：
LECHNER, H
中科院分区：
文献类型：
--
作者：
SCHMIDT, R;FAZEKAS, F;LECHNER, H
为了确定MRI白色高信号（WMH）对认知功能的影响，我们使用神经心理测试和MRI研究了150名无神经精神疾病或全身疾病的老年志愿者。无WMH者76例（50.3%），有WMH者74例（49.7%）。后一个子集年龄更大（61.3 +/- 6.6岁vs 58.5 +/- 5.8岁，p = 0.005），平均动脉血压较高（103.7 +/- 11.4 mm Hg vs 99.9 +/- 10.3 mm Hg，p = 0.03），脑室-颅内腔比更大（6.3 ± 5.6% vs 4.7 ± 1.6%，p = 0.02）。WMH的个人表现比他们的同行没有这样的异常在所有测试管理。在调整了年龄、动脉血压和心室大小的组间差异后，我们注意到连线测试的B表中的统计学显著性结果（121.8 +/- 37.8 msec vs 100.3 +/- 47.9 msec，p = 0.04），复杂反应时间任务（680.8 +/- 104.9 msec vs 607.1 +/- 93.9 msec，p = 0.001）和Purdue钉板测试的组装程序（27.5 +/- 5.8 vs 30.6 +/- 5.9，p +/- 0.02）。偏相关分析没有发现任何关系之间的测试成绩和半自动评估的总面积WMH。我们的数据表明，WMH的存在对正常老年人的神经心理学表现产生了微妙的影响，这在测量更复杂的心理处理速度的任务上变得特别明显。
To determine the effects of MRI white matter hyperintensities (WMH) on cognitive functioning, we used neuropsychlogic tests and MRI to study 150 elderly volunteers free of neuropsychiatric or general disease. There were 76 (50.3%) individuals without and 74 (49.7%) with WMH. The latter subset was older (61.3 +/- 6.6 years versus 58.5 +/- 5.8 years, p = 0.005), had a higher mean arterial blood pressure (103.7 +/- 11.4 mm Hg versus 99.9 +/- 10.3 mm Hg, p = 0.03), and a larger ventricular-to-intracranial-cavity ratio (6.3 +/-5.6% versus 4.7 +/- 1.6%, p = 0.02). Individuals with WMH performed worse than their counterparts without such abnormalities on all tests administered. After adjusting for the group differences in age, arterial blood pressure, and ventricular size, we noted statistically significant results on form B of the Trail Making Test (121.8 +/- 37.8 msec versus 100.3 +/- 47.9 msec, p = 0.04), a complex reaction time task (680.8 +/- 104.9 msec versus 607.1 +/- 93.9 msec, p = 0.001), and the assembly procedure of the Purdue Pegboard Test (27.5 +/- 5.8 versus 30.6 +/- 5.9, p +/- 0.02). Partial correlations did not reveal any relationship between test scores and the semiautomatically assessed total area of WMH. Our data suggest that the presence of WMH exerts a subtle effect on neuropsychologic performance of normal elderly individuals, which becomes particularly evident on tasks measuring the speed of more complex mental processing.