Case of autoimmune progesterone dermatitis presenting as fixed drug eruption
Case of autoimmune progesterone dermatitis presenting as fixed drug eruption
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DOI：
10.1111/j.1346-8138.2009.00723.x
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发表时间：
2009-12-01
影响因子：
3.1
通讯作者：
Kishimoto, Saburo
中科院分区：
文献类型：
--
作者：
Asai, Jun;Katoh, Norito;Kishimoto, Saburo
自身免疫性黄体酮皮炎是一种罕见的疾病，表现为周期性皮疹在黄体期的月经周期。它通常发生在妇女由于自身免疫现象，内源性孕酮的生产。我们描述了一名34岁女性，左臂同一部位出现带有水泡的红色圆形斑块，在月经周期前几天复发。通过皮下注射诊断为自身免疫性黄体酮皮炎用黄体酮对受影响的病变进行皮肤测试。月经期间开始口服泼尼松龙（40 mg/d）治疗后，虽然出现轻微复发，但严重程度明显改善。
Autoimmune progesterone dermatitis is a rare disorder that presents as a cyclical cutaneous eruption during the luteal phase of the menstrual cycle. It typically occurs in women due to an autoimmune phenomenon to endogenous progesterone production. We describe a 34-year-old woman with an erythematous round plaque with blistering, which recurred a few days before her menstrual cycle, at the identical site on the left arm. The diagnosis of autoimmune progesterone dermatitis is made with i.d. skin testing on the affected lesion with progesterone. After the beginning of oral prednisolone (40 mg daily) therapy during menstruation, although slight recurrence appeared, the severity was significantly improved.