Dishevelled and Wnt signaling: is the nucleus the final frontier?
Dishevelled and Wnt signaling: is the nucleus the final frontier?
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DOI:
10.1186/jbiol22
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发表时间:
2005
影响因子:
--
通讯作者:
Dawid IB
中科院分区:
文献类型:
--
作者:
Habas R;Dawid IB
The phosphoprotein Dishevelled (Dsh) is an essential component of Wnt signaling pathways and transduces signals into three separate branches, the canonical, non-canonical and Ca2+ pathways. How Dsh focuses signaling into these branches remains mysterious, but a new study reveals the importance of nuclear localization of Dsh for pathway-specific activation.