Dishevelled and Wnt signaling: is the nucleus the final frontier?

Dishevelled and Wnt signaling: is the nucleus the final frontier?
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DOI:
10.1186/jbiol22
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发表时间:
2005
期刊:
影响因子:
--
通讯作者:
Dawid IB
Dawid IB
中科院分区:
其他
文献类型:
--
作者:
Habas R;Dawid IB

文献摘要

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磷酸化蛋白disheveled (Dsh)是Wnt信号通路的重要组成部分,并将信号转导到三个独立的分支,即典型、非典型和Ca2+通路。Dsh如何将信号聚焦到这些分支仍然是一个谜,但一项新的研究揭示了Dsh的核定位对途径特异性激活的重要性。
The phosphoprotein Dishevelled (Dsh) is an essential component of Wnt signaling pathways and transduces signals into three separate branches, the canonical, non-canonical and Ca2+ pathways. How Dsh focuses signaling into these branches remains mysterious, but a new study reveals the importance of nuclear localization of Dsh for pathway-specific activation.