EXPERIMENTAL-DESIGN IN ALCOHOL ADMINISTRATION RESEARCH - LIMITATIONS AND ALTERNATIVES IN THE MANIPULATION OF DOSAGE-SET
EXPERIMENTAL-DESIGN IN ALCOHOL ADMINISTRATION RESEARCH - LIMITATIONS AND ALTERNATIVES IN THE MANIPULATION OF DOSAGE-SET
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DOI：
10.15288/jsa.1993.54.750
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发表时间：
1993-11-01
期刊：
影响因子：
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通讯作者：
SAYETTE, MA
中科院分区：
文献类型：
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作者：
MARTIN, CS;SAYETTE, MA
本文综述了人类酒精给药研究中不同实验设计的效用，特别是平衡安慰剂设计（BPD）。许多人认为BPD可以正交操纵酒精的药理作用和剂量设定的影响（相信一个人已经消耗了一定量的酒精）。然而，越来越多的研究表明，这些影响在中等到高剂量的酒精中无法解开。一些实验设计的优点和缺点进行了讨论方面的设计可以评估或控制的变量。欺骗条件和操纵检查的方法问题进行了审查。需要实证研究的主题突出。它的结论是，适当的酒精管理设计取决于特定的理论和方法问题的研究计划。
This article reviews literature on the utility of different experimental designs in human alcohol administration research, with particular attention to the balanced-placebo design (BPD). Many believe the BPD can orthogonally manipulate alcohol's pharmacological effects and the effects of dosage-set (believing that one has consumed a certain amount of alcohol). However, research has accumulated that suggests these effects cannot be disentangled at moderate to high doses of alcohol. The strengths and weaknesses of a number of experimental designs are discussed with regard to the variables that designs can assess or control. Methodological issues in deception conditions and manipulation checks are reviewed. Topics in need of empirical investigation are highlighted. It is concluded that the appropriate alcohol administration design depends on the particular theoretical and methodological issues of a research program.