Meta-analysis of the association of Trp64Arg polymorphism of β3-adrenergic receptor gene with body mass index
Meta-analysis of the association of Trp64Arg polymorphism of β3-adrenergic receptor gene with body mass index
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DOI：
10.1210/jc.83.7.2441
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发表时间：
1998-07-01
影响因子：
5.8
通讯作者：
Ogihara, T
中科院分区：
文献类型：
--
作者：
Fujisawa, T;Ikegami, H;Ogihara, T
据报道，β（3）-肾上腺素能受体基因（Trp（64）Arg）中的一种可能致病的多态性与体重增加、胰岛素抵抗的临床特征和几个人群中2型糖尿病的早期发展相关。然而，这些发现在研究中并不一致，使得这种遗传标记与临床特征相关的假设存在争议。为了评估基因型对身体质量指数（BMI）的影响，我们对文献数据进行了荟萃分析，采用ANOVA扩展进行连续测量。在总共48个亚组中，（n = 2447）和无（n = 6789）Trp（64）Arg变体，BMI的汇总加权平均差异为0.30（95%置信区间，0.13-0.47）kg/m2，表明变异携带者表现出更高的BMI（平均高0.30 kg/m2）。在这种情况下，没有显著证据反对效果的同质性（P = 0.36）。这是第一个评估与遗传多态性相关的定量表型的荟萃分析，结果支持Trp（64）Arg多态性与不同人群的BMI相关的假设，表明β 1肾上腺素能受体基因座在普遍的体重增加遗传易感性中发挥作用。
A possible pathogenic polymorphism in the beta(3)-adrenergic receptor gene (Trp(64)Arg) has been reported to be associated with increased body weight, clinical features of insulin resistance, and early development of type 2 diabetes mellitus in several populations. However, such findings have not been consistent among studies, making the hypothesis that this genetic marker is associated with clinical features controversial. To assess the effect of the genotypes on body mass index (BMI), we performed a meta-analysis of the data from the literature using an extension of ANOVA for continuous measures. In a total of 48 subgroups containing subjects with (n = 2447) and without (n = 6789) the Trp(64)Arg variant, the summary weighted mean difference in BMI was 0.30 (95% confidence interval, 0.13-0.47) kg/m(2), indicating that variant carriers exhibited higher BMI (on the average, 0.30 kg/m(2) higher) than normal homozygous subjects. In this case, there was no significant evidence against homogeneity of the effect (P = 0.36). This is the first meta-analysis assessing quantitative phenotypes in relation to a genetic polymorphism, and the results support the hypothesis that the Trp(64)Arg polymorphism is associated with BMI across diverse population groups, suggesting that the P,adrenergic receptor gene locus plays a role in genetic predisposition to increased body weight in a universal manner.